Pereira Olívia R, Macias Rocio I R, Domingues Maria R M, Marin Jose J G, Cardoso Susana M
Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal.
Laboratory of Experimental Hepatology and Drug Targeting, IBSAL, CIBERehd, University of Salamanca, 37007 Salamanca, Spain.
Antioxidants (Basel). 2019 Aug 2;8(8):267. doi: 10.3390/antiox8080267.
The phenolic composition of hydroethanolic extracts of L., L. and L., obtained from plants grown under organic cultivation, was determined and their hepatoprotective effects were investigated in vitro. extract was rich in phenylethenoid glycosides, especially lavandolifolioside (254 ± 36 μg/mg), whereas rosmarinic acid and eriodictyol--rutinoside were the major phenolic compounds of and extracts, accounting for 68 ± 7 μg/mg and 145 ± 22 μg/mg, respectively. These differential phenolic components presumably account for their dissimilar antioxidant properties. While extract showed moderate biological effects, extract displayed high antioxidant activity in chemical models, and that of was effective in counteracting potassium dichromate-induced ROS generation in human hepatocarcinoma cells. Moreover, extract (50 μg/mL) and its mixture (50%/50%) with extract displayed an effective cytoprotective effect.
测定了从有机种植的植物中获得的薰衣草、迷迭香和百里香乙醇提取物的酚类成分，并在体外研究了它们的肝保护作用。薰衣草提取物富含苯乙烯类糖苷，尤其是薰衣草叶苷（254±36μg/mg），而迷迭香酸和圣草酚-芸香糖苷分别是迷迭香和百里香提取物的主要酚类化合物，含量分别为68±7μg/mg和145±22μg/mg。这些不同的酚类成分可能是它们不同抗氧化特性的原因。虽然薰衣草提取物显示出中等的生物学效应，但迷迭香提取物在化学模型中表现出高抗氧化活性，百里香提取物在抵消重铬酸钾诱导的人肝癌细胞中活性氧生成方面有效。此外，百里香提取物（50μg/mL）及其与薰衣草提取物的混合物（50%/50%）显示出有效的细胞保护作用。
