Gellert A R, Langford J A, Winter R J, Lewis C A, Tolfree S E, Rudd R M
Br J Dis Chest. 1985 Jan;79(1):37-42. doi: 10.1016/0007-0971(85)90005-1.
The half-time clearance of an inhaled aerosol of 99m-technetium-labelled diethylene triamine pentacetate from lung to blood (T1/2LB) was measured using a gamma camera in 20 non-smoking subjects (mean age 54, range 40-69 years) with previous occupational asbestos exposure, but no clinical or radiological evidence of asbestosis, and 20 non-smoking normal subjects (mean age 54, range 40-62). Mean T1/2LB was 44.7 minutes (range 12-102) in exposed subjects, significantly less than 57.2 minutes (range 30.5-109) in normal subjects (P less than 0.05). There was no correlation between age and T1/2LB in either group. In exposed subjects T1/2LB showed a weak rank correlation with the membrane component of DLco (Dm) (r = 0.40, P less than 0.05) but no significant correlation with FVC, TLC, DLco, Kco, resting Pao2 or change in Pao2 on exercise. In six exposed subjects T1/2LB was shorter than in any of the normal subjects. These six did not differ from the other 14 exposed subjects in any physiological variables. T1/2LB is abnormal in some asbestos-exposed subjects without clinical, radiological or physiological evidence of asbestosis. Follow-up will show whether it is an early indicator of development of interstitial lung disease.
采用γ相机对20名既往有职业性石棉接触史但无石棉肺临床或放射学证据的非吸烟受试者（平均年龄54岁，范围40 - 69岁）以及20名非吸烟正常受试者（平均年龄54岁，范围40 - 62岁）进行测量，以测定99m - 锝标记的二乙三胺五乙酸吸入气雾剂从肺到血液的半衰期清除率（T1/2LB）。暴露组受试者的平均T1/2LB为44.7分钟（范围12 - 102分钟），显著低于正常受试者的57.2分钟（范围30.5 - 109分钟）（P < 0.05）。两组中年龄与T1/2LB均无相关性。在暴露组受试者中，T1/2LB与一氧化碳弥散量（DLco）的膜成分（Dm）呈弱等级相关性（r = 0.40，P < 0.05），但与用力肺活量（FVC）、肺总量（TLC）、DLco、一氧化碳弥散系数（Kco）、静息动脉血氧分压（Pao2）或运动时Pao2的变化均无显著相关性。在6名暴露组受试者中，T1/2LB比任何一名正常受试者都短。这6名受试者在任何生理变量方面与其他14名暴露组受试者均无差异。在一些无石棉肺临床、放射学或生理学证据的石棉暴露受试者中，T1/2LB异常。随访将表明它是否是间质性肺病发展的早期指标。
