Handa Tomoko, Onoue Takeshi, Maeda Ryutaro, Mizutani Keigo, Suzuki Koji, Kobayashi Tomoko, Miyata Takashi, Sugiyama Mariko, Hagiwara Daisuke, Iwama Shintaro, Suga Hidetaka, Banno Ryoichi, Arima Hiroshi
Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
Department of Clinical Research Education, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
Nutrients. 2025 Jan 7;17(2):202. doi: 10.3390/nu17020202.
In treating obesity, energy intake control is essential to avoid exceeding energy expenditure. However, excessive restriction of energy intake often leads to resting energy expenditure (REE) reduction, increasing hunger and making weight loss difficult. This study aimed to investigate whether providing nutritional guidance that considers energy expenditure based on the regular evaluation of REE and physical activity could effectively reduce body weight (BW) in patients with obesity.
A single-arm, prospective interventional study was conducted on 20 patients with obesity (body mass index ≥ 25 kg/m) at the Nagoya University Hospital for 24 weeks. REE and physical activity were regularly assessed, and the recommended energy intake was adjusted based on the values. The primary outcome was the change in BW, and the secondary outcomes included changes in REE and hunger ratings, which were assessed using a visual analog scale.
Eighteen participants completed the study, demonstrating a significant reduction in BW after 24 weeks (-5.34 ± 6.76%, < 0.0001). No significant changes were observed in REE or hunger ratings. No adverse events were reported throughout the study period.
Guidance on energy intake based on REE and physical activity was effective for reducing BW in patients with obesity without decreasing REE or increasing hunger. This approach may reduce the burden on patients with obesity while losing BW.
在治疗肥胖症时，控制能量摄入对于避免超过能量消耗至关重要。然而，过度限制能量摄入往往会导致静息能量消耗（REE）降低，增加饥饿感并使体重减轻变得困难。本研究旨在调查基于对REE和身体活动的定期评估提供考虑能量消耗的营养指导是否能有效降低肥胖患者的体重（BW）。
在名古屋大学医院对20名肥胖患者（体重指数≥25kg/m²）进行了一项单臂前瞻性干预研究，为期24周。定期评估REE和身体活动，并根据评估值调整推荐的能量摄入量。主要结局是BW的变化，次要结局包括REE和饥饿评分的变化，使用视觉模拟量表进行评估。
18名参与者完成了研究，24周后BW显著降低（-5.34±6.76%，<0.0001）。REE或饥饿评分未观察到显著变化。在整个研究期间未报告不良事件。
基于REE和身体活动的能量摄入指导对于降低肥胖患者的BW有效，且不会降低REE或增加饥饿感。这种方法可能会在肥胖患者减轻体重的同时减轻其负担。
