Walawska-Hrycek Anna, Hrycek Eugeniusz, Galus Weronika, Jędrzejowska-Szypułka Halina, Krzystanek Ewa
Department of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.
Department of Cardiology, Faculty of Medical Sciences, Andrzej Frycz Modrzewski Kraków University, 30-705 Kraków, Poland.
Nutrients. 2025 Jan 19;17(2):352. doi: 10.3390/nu17020352.
Calcitriol, beyond its well-established role in calcium and phosphate homeostasis, contributes to immunological processes. No known vitamin D dosage regimen effectively corrects the deficiency while accounting for immunoregulatory effects. Therefore, the purpose of this assessment was to determine whether regular administration of low doses of vitamin D might correct deficiency and have immunoregulatory effects.
A total of 35 healthy volunteers were asked to supplement with vitamin D daily at a dosage of 500 or 1000 IU, depending on the degree of deficiency, for 12 months. At the beginning of the study and after the end of the supplementation period, concentrations of 25(OH)D; PTH; total calcium; inorganic phosphorus; and the inflammatory cytokines IL-17, IL-10, TGF-β, and IFN-γ were determined in all participants.
Correction of vitamin D deficiency was achieved with accompanying decreases in PTH and pro-inflammatory cytokine concentrations, while the concentration of anti-inflammatory cytokines remained stable.
Therefore, regular vitamin D supplementation, even in small doses, effectively corrected the deficiency and had immunomodulatory effects.
骨化三醇除了在钙和磷稳态中具有公认的作用外，还参与免疫过程。目前尚无已知的维生素D给药方案能在考虑免疫调节作用的同时有效纠正维生素D缺乏。因此，本评估的目的是确定定期给予低剂量维生素D是否能纠正维生素D缺乏并产生免疫调节作用。
根据维生素D缺乏程度，共35名健康志愿者被要求每日补充500或1000国际单位的维生素D，持续12个月。在研究开始时和补充期结束后，测定所有参与者的25(OH)D、甲状旁腺激素（PTH）、总钙、无机磷以及炎性细胞因子白细胞介素-17（IL-17）、白细胞介素-10（IL-10）、转化生长因子-β（TGF-β）和干扰素-γ（IFN-γ）的浓度。
维生素D缺乏得到纠正，同时PTH和促炎细胞因子浓度降低，而抗炎细胞因子浓度保持稳定。
因此，即使是小剂量的定期维生素D补充也能有效纠正维生素D缺乏并产生免疫调节作用。
