Cvetković Maja, Miladinović Bojana, Branković Suzana, Randjelović Milica, Živanović Slavoljub, Kitić Nemanja, Milutinović Milica, Jovanović Miloš, Stojanović Dušica, Nikšić Haris, Šavikin Katarina, Kitić Dušanka
Department of Pharmacy, Faculty of Medicine, University of Niš, Dr. Zoran Djindjić Ave 81, 18000 Niš, Serbia.
Department of Physiology, Faculty of Medicine, University of Niš, Dr. Zoran Djindjić Ave 81, 18000 Niš, Serbia.
Plants (Basel). 2025 Jan 16;14(2):234. doi: 10.3390/plants14020234.
Red currant ( L.) berries are rich in bioactive compounds and exhibit nutritive and protective features. This research examined the content of secondary metabolites of the red currant variety Redpoll lyophilized juice and waste extract and their antioxidative and spasmolytic effects. The flavonol and anthocyanin contents of the samples were determined using high-performance liquid chromatography. The antispasmodic effects were assessed in in vitro conditions, and the potential impact of the samples and possible action mechanisms were revealed. The results showed the prevalence of cyanidin-3--glucoside as the dominant anthocyanin with higher content in the juice sample. Quercetin content, as the prevalent flavonol, was higher in the waste sample. The berry juice showed a greater ability for scavenging free radicals, whereas the waste better inhibited lipid peroxidation. The juice was a superior antispasmodic agent for spontaneous, KCl-, CaCl-, BaCl-, histamine-, and acetylcholine-induced ileal contractions. This first evaluation of the red currant variety Redpoll lyophilized juice and waste extract indicated the beneficial effects of juice as an antioxidant and spasmolytic agent. Therefore, this red currant juice sample could be designated for the prevention or treatment of gastrointestinal disorders.
红醋栗（L.）浆果富含生物活性化合物，具有营养和保护特性。本研究检测了红醋栗品种红顶雀冻干汁和废渣提取物中次生代谢产物的含量及其抗氧化和解痉作用。采用高效液相色谱法测定样品中的黄酮醇和花青素含量。在体外条件下评估解痉作用，并揭示样品的潜在影响和可能的作用机制。结果表明，矢车菊素-3-葡萄糖苷作为主要花青素在果汁样品中含量较高。槲皮素作为主要的黄酮醇，在废渣样品中的含量较高。浆果汁清除自由基的能力更强，而废渣对脂质过氧化的抑制作用更好。该果汁是自发性、氯化钾、氯化钙、氯化钡、组胺和乙酰胆碱诱导的回肠收缩的更优解痉剂。对红醋栗品种红顶雀冻干汁和废渣提取物的首次评估表明，果汁作为抗氧化剂和解痉剂具有有益作用。因此，这种红醋栗汁样品可用于预防或治疗胃肠道疾病。
