Radeva Lyubomira, Yoncheva Krassimira
Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria.
Pharmaceutics. 2025 Jan 19;17(1):134. doi: 10.3390/pharmaceutics17010134.
Resveratrol is a natural polyphenol (stilbenoid), which can be found in grape skin, red wine, blueberries, peanuts and others. The biological properties of resveratrol, in particular antioxidant, anti-inflammatory, anticancer, estrogenic, vasorelaxant and cardioprotective activity, are the main reason for its importance in medicine and pharmacy. Despite all of its advantages, however, there are many problems related to this polyphenolic substance, such as low stability, water insolubility, poor bioavailability and fast metabolism. For this reason, scientists are currently searching for different approaches to dealing with these problematic properties and improving the therapeutic usage of resveratrol. This review summarizes the mechanisms of the biological effects of resveratrol, determined in vitro and in vivo, and the main limitations of the drug. The article emphasizes new approaches for the improvement of resveratrol delivery, in particular nanoencapsulation, formation of nanocrystals, prodrugs and structure analogues.
白藜芦醇是一种天然多酚（芪类化合物），存在于葡萄皮、红酒、蓝莓、花生等之中。白藜芦醇的生物学特性，特别是抗氧化、抗炎、抗癌、雌激素样、血管舒张和心脏保护活性，是其在医学和药学中重要性的主要原因。然而，尽管它有诸多优点，但这种多酚类物质存在许多问题，如稳定性低、水不溶性、生物利用度差和代谢快。因此，科学家目前正在寻找不同方法来处理这些问题特性，并改善白藜芦醇的治疗用途。本综述总结了在体外和体内确定的白藜芦醇生物效应机制以及该药物的主要局限性。文章强调了改善白藜芦醇递送的新方法，特别是纳米包封、纳米晶体形成、前药和结构类似物。
