Branda Francesco, Ali Abdisalam Yusuf, Ceccarelli Giancarlo, Albanese Mattia, Binetti Erica, Giovanetti Marta, Ciccozzi Massimo, Scarpa Fabio
Unit of Medical Statistics and Molecular Epidemiology, Università Campus Bio-Medico di Roma, 00128 Rome, Italy.
School of Public Health, Mount Kenya University, Thika P.O. Box 342-01000, Kenya.
Viruses. 2024 Dec 28;17(1):29. doi: 10.3390/v17010029.
Neglected tropical diseases (NTDs) represent a group of chronic and debilitating infections that affect more than one billion people, predominantly in low-income communities with limited health infrastructure. This paper analyzes the factors that perpetuate the burden of NTDs, highlighting how poor health infrastructure, unfavorable socioeconomic conditions and lack of therapeutic resources exacerbate their impact. The effectiveness of current interventions, such as mass drug administration (MDA) programs and improved sanitation, in reducing disease prevalence is examined. In addition, the role of climate change, which alters transmission dynamics and expands affected territories, is discussed as an emerging challenge. The analysis suggests that integrated, multisectoral approaches, including health education and infrastructure interventions, are essential to breaking the cycle of poverty and disease. Although international programs have marked significant progress, achieving elimination targets by 2030 requires sustained commitment, innovation, and increased research capacity in endemic countries.
被忽视的热带病（NTDs）是一类慢性且使人衰弱的感染性疾病，影响着超过十亿人，主要集中在卫生基础设施有限的低收入社区。本文分析了使NTDs负担持续存在的因素，强调了卫生基础设施差、不利的社会经济条件和治疗资源匮乏如何加剧其影响。研究了当前干预措施，如大规模药物给药（MDA）计划和改善环境卫生，在降低疾病流行率方面的有效性。此外，还讨论了气候变化这一新兴挑战的作用，它改变了传播动态并扩大了受影响地区。分析表明，包括健康教育和基础设施干预在内的综合多部门方法对于打破贫困与疾病的循环至关重要。尽管国际项目已取得显著进展，但到2030年实现消除目标需要流行国家持续的投入、创新和增强研究能力。
