The Biodesign Center for Fundamental and Applied Microbiomics, Center for Evolution and Medicine and School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA.
Panthera, 8 W 40th St, 18th Floor, New York, NY 10018, USA.
Viruses. 2024 Apr 29;16(5):701. doi: 10.3390/v16050701.
Papillomaviruses (PV) infect epithelial cells and can cause hyperplastic or neoplastic lesions. In felids, most described PVs are from domestic cats (; n = 7 types), with one type identified in each of the five wild felid species studied to date (, , , and ). PVs from domestic cats are highly diverse and are currently classified into three genera (, , and ), whereas those from wild felids, although diverse, are all classified into the genus. In this study, we used a metagenomic approach to identify ten novel PV genomes from rectal swabs of five deceased caracals () living in the greater Cape Town area, South Africa. These are the first PVs to be described from caracals, and represent six new PV types, i.e., Caracal caracal papillomavirus (CcarPV) 1-6. These CcarPV fall into two phylogenetically distinct genera: , and . Two or more PV types were identified in a single individual for three of the five caracals, and four caracals shared at least one of the same PV types with another caracal. This study broadens our understanding of wild felid PVs and provides evidence that there may be several wild felid PV lineages.
乳头瘤病毒（PV）感染上皮细胞，可引起增生性或肿瘤性病变。在猫科动物中，大多数描述的 PV 来自家猫（n=7 种），迄今为止在五种野生猫科动物中都发现了一种（、、、和）。来自家猫的 PV 高度多样化，目前分为三个属（、、和），而来自野生猫科动物的 PV 虽然多样化，但都归为属。在这项研究中，我们使用宏基因组学方法从生活在南非开普敦地区的五只死亡的卡拉卡尔（）的直肠拭子中鉴定出了十种新型 PV 基因组。这是首次从卡拉卡尔中描述的 PV，代表六种新的 PV 类型，即卡拉卡尔乳头瘤病毒（CcarPV）1-6。这些 CcarPV 分为两个在系统发育上截然不同的属：和。在五个卡拉卡尔中的三个中，一个个体中鉴定出两种或更多种 PV 类型，四个卡拉卡尔与另一个卡拉卡尔共享至少一种相同的 PV 类型。本研究拓宽了我们对野生猫科动物 PV 的认识，并提供了证据表明可能存在几种野生猫科动物的 PV 谱系。
