Ambagaspitiya Sankalya S, Appuhamillage Gayan A, Wimalawansa Sunil J
Department of Biosystems Technology, Faculty of Technology, University of Sri Jayewardenepura, 10206 Homagama, Sri Lanka.
Department of Materials and Mechanical Technology, Faculty of Technology, University of Sri Jayewardenepura, 10206 Homagama, Sri Lanka.
Front Biosci (Landmark Ed). 2025 Jan 20;30(1):25463. doi: 10.31083/FBL25463.
Human skin is a physical and biochemical barrier that protects the internal body from the external environment. Throughout a person's life, the skin undergoes both intrinsic and extrinsic aging, leading to microscopic and macroscopic changes in its morphology. In addition, the repair processes slow with aging, making the older population more susceptible to skin diseases. Intrinsic factors associated with advanced age gradually degrade the dermal collagen matrix, resulting in fine wrinkles and reduced elasticity; this is accelerated in post-menopausal women due to estrogen deficiency. In contrast, extrinsic factors associated with advanced age, primarily caused by exposure to ultraviolet (UV) radiation, lead to coarse wrinkles, solar elastosis, hyperkeratosis, irregular pigmentation, and skin cancers. UVB radiation, while contributing to skin photo-aging, also induces the cutaneous synthesis of vitamin D. Vitamin D, in turn, protects the skin from oxidative stress, inflammation, and DNA damage, thereby delaying both chronological and photo-aging. Moreover, research has demonstrated an association between lower vitamin D levels and a higher prevalence of certain cutaneous diseases. This review explores and summarizes the critical role of vitamin D in skin aging and age-related skin diseases. The data presented highlight the importance of maintaining vitamin D adequacy throughout life.
人类皮肤是一种物理和生化屏障，可保护身体内部免受外部环境影响。在人的一生中，皮肤会经历内在和外在老化，导致其形态发生微观和宏观变化。此外，随着年龄增长，修复过程会减缓，使老年人群更容易患皮肤病。与高龄相关的内在因素会逐渐降解真皮胶原蛋白基质，导致出现细纹和弹性降低；由于雌激素缺乏，绝经后女性的这种情况会加速。相比之下，与高龄相关的外在因素主要由紫外线（UV）辐射暴露引起，会导致粗皱纹、日光性弹力纤维变性、角化过度、色素沉着不规则和皮肤癌。UVB辐射在导致皮肤光老化的同时，还会诱导皮肤合成维生素D。反过来，维生素D可保护皮肤免受氧化应激、炎症和DNA损伤，从而延缓自然老化和光老化。此外，研究表明维生素D水平较低与某些皮肤病的较高患病率之间存在关联。本综述探讨并总结了维生素D在皮肤老化和与年龄相关的皮肤病中的关键作用。所呈现的数据凸显了终生维持充足维生素D水平的重要性。
