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营养与营养补充剂在慢性阻塞性肺疾病营养不良防治中的作用:营养治疗的当前方法

The Role of Nutrition and Nutritional Supplements in the Prevention and Treatment of Malnutrition in Chronic Obstructive Pulmonary Disease: Current Approaches in Nutrition Therapy.

作者信息

Tuna Tuğba, Samur Gülhan

机构信息

Faculty of Health Sciences, Department of Nutrition and Dietetics, Mudanya University, Bursa, Turkey.

Faculty of Health Sciences, Department of Nutrition and Dietetics, Hacettepe University, Ankara, Turkey.

出版信息

Curr Nutr Rep. 2025 Jan 25;14(1):21. doi: 10.1007/s13668-025-00613-8.

Abstract

PURPOSE OF REVIEW

Malnutrition is a significant comorbidity in Chronic Obstructive Pulmonary Disease (COPD), contributing to disease progression and reduced quality of life. This narrative review examines the role of nutritional therapy in the prevention and management of malnutrition in COPD, emphasizing evidence-based approaches and their clinical implications.

RECENT FINDINGS

COPD patients face increased metabolic demands, systemic inflammation, and reduced dietary intake, resulting in muscle wasting, sarcopenia, and cachexia. Recent evidence highlights the efficacy of targeted nutritional strategies, including essential amino acid supplementation, omega-3 fatty acids, vitamin D, and antioxidants, in improving respiratory function, muscle strength, and patient well-being. Comprehensive nutritional assessments and personalized interventions are increasingly recognized as critical components of COPD care. However, long-term efficacy data remain limited. Nutritional therapy plays a pivotal role in managing malnutrition and improving clinical outcomes in COPD. This review synthesizes the latest evidence, identifies gaps in current research, and proposes strategies for integrating personalized nutrition into COPD care. Future studies are needed to establish the long-term benefits of these interventions and to develop tailored nutritional guidelines for COPD patients.

摘要

综述目的

营养不良是慢性阻塞性肺疾病(COPD)的一种重要合并症,会导致疾病进展并降低生活质量。本叙述性综述探讨营养治疗在COPD营养不良预防和管理中的作用,强调循证方法及其临床意义。

最新研究结果

COPD患者面临代谢需求增加、全身炎症和饮食摄入减少的问题,导致肌肉萎缩、肌少症和恶病质。最近的证据强调了有针对性的营养策略的有效性,包括补充必需氨基酸、ω-3脂肪酸、维生素D和抗氧化剂,这些策略在改善呼吸功能、肌肉力量和患者健康方面具有重要作用。全面的营养评估和个性化干预越来越被认为是COPD护理的关键组成部分。然而,长期疗效数据仍然有限。营养治疗在管理COPD患者的营养不良和改善临床结局方面起着关键作用。本综述综合了最新证据,确定了当前研究中的差距,并提出了将个性化营养纳入COPD护理的策略。未来需要开展研究以确定这些干预措施的长期益处,并为COPD患者制定量身定制的营养指南。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac86/11762775/2fc4626322b2/13668_2025_613_Fig1_HTML.jpg

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