French T J, Goode A W, Schofield P S, Sugden M C
Biosci Rep. 1985 Jan;5(1):47-55. doi: 10.1007/BF01117440.
The liver is the sole site of carnitine biosynthesis in the rat. However, the first 24 h after the surgical removal of two-thirds of the liver mass are not associated with depletion of carnitine either in the liver remnant or in a number of extrahepatic tissues with relatively short turnover times of carnitine (less than 24 h; heart, spleen, kidney). Dietary carnitine was not supplied. The results suggest that the capacity of the remnant liver for carnitine biosynthesis is sufficient to maintain tissue carnitine contents. Liver regeneration influenced the relative proportions of hepatic free and acylated carnitines in a manner compatible with changes in fat disposition in the proliferating tissue.
肝脏是大鼠体内肉碱生物合成的唯一部位。然而，手术切除三分之二肝脏组织后的最初24小时内，无论是肝脏残余组织还是一些肉碱周转时间相对较短（少于24小时；心脏、脾脏、肾脏）的肝外组织，肉碱都没有出现消耗。未提供膳食肉碱。结果表明，残余肝脏的肉碱生物合成能力足以维持组织中的肉碱含量。肝脏再生对肝脏游离肉碱和酰化肉碱的相对比例产生了影响，这种影响方式与增殖组织中脂肪分布的变化相一致。
