French T J, Good A W, Palmer T N, Sugden M C
Biosci Rep. 1985 Sep;5(9):729-34. doi: 10.1007/BF01119870.
The in vivo effects of dexamethasone administration on liver and extrahepatic tissue carnitine concentrations were assessed in 48-h-starved rats. In heart and kidney, but not in liver, dexamethasone significantly increased total carnitine concentration. Acute (2.5 h) treatment with 2-tetradecylglycidate (TDG), a specific inhibitor of carnitine palmitoyl transferase 1, not only increased total hepatic carnitine concentrations, but also permitted an effect of dexamethasone (a further increase in hepatic carnitine concentration). The results are discussed in terms of acute (substrate-mediated) and chronic (hormonal) control of carnitine turnover.
在地塞米松给药对48小时饥饿大鼠肝脏和肝外组织肉碱浓度的体内效应进行了评估。在心脏和肾脏中，而不是在肝脏中，地塞米松显著增加了总肉碱浓度。用肉碱棕榈酰转移酶1的特异性抑制剂2-十四烷基缩水甘油酸酯（TDG）进行急性（2.5小时）处理，不仅增加了肝脏总肉碱浓度，还使地塞米松产生了作用（肝脏肉碱浓度进一步增加）。从肉碱周转的急性（底物介导）和慢性（激素）控制方面对结果进行了讨论。
