The current work introduces the hybrid ensemble framework for the detection and segmentation of colorectal cancer. This framework will incorporate both supervised classification and unsupervised clustering methods to present more understandable and accurate diagnostic results. The method entails several steps with CNN models: ADa-22 and AD-22, transformer networks, and an SVM classifier, all inbuilt. The CVC ClinicDB dataset supports this process, containing 1650 colonoscopy images classified as polyps or non-polyps. The best performance in the ensembles was done by the AD-22 + Transformer + SVM model, with an AUC of 0.99, a training accuracy of 99.50%, and a testing accuracy of 99.00%. This group also saw a high accuracy of 97.50% for Polyps and 99.30% for Non-Polyps, together with a recall of 97.80% for Polyps and 98.90% for Non-Polyps, hence performing very well in identifying both cancerous and healthy regions. The framework proposed here uses K-means clustering in combination with the visualisation of bounding boxes, thereby improving segmentation and yielding a silhouette score of 0.73 with the best cluster configuration. It discusses how to combine feature interpretation challenges into medical imaging for accurate localization and precise segmentation of malignant regions. A good balance between performance and generalization shall be done by hyperparameter optimization-heavy learning rates; dropout rates and overfitting shall be suppressed effectively. The hybrid schema of this work treats the deficiencies of the previous approaches, such as incorporating CNN-based effective feature extraction, Transformer networks for developing attention mechanisms, and finally the fine decision boundary of the support vector machine. Further, we refine this process via unsupervised clustering for the purpose of enhancing the visualisation of such a procedure. Such a holistic framework, hence, further boosts classification and segmentation results by generating understandable outcomes for more rigorous benchmarking of detecting colorectal cancer and with higher reality towards clinical application feasibility.