Ryvniak V V
Biull Eksp Biol Med. 1985 Apr;99(4):490-1.
Experiments on mice have demonstrated ultrastructural changes in collagen and hepatocytes during reverse development of liver cirrhosis. Progressive lysis of collagenous fibers has been noted. Changes in hepatocytes point to a rise in the synthetic and endocytosis activity in these cells. It is suggested that exocellular lysis of collagen in the process under consideration is initiated by collagenase whereas subsequently it takes place under the action of lysosomal enzymes secreted by hepatocytes to the exocellular space.
对小鼠的实验已经证明了肝硬化逆向发展过程中胶原蛋白和肝细胞的超微结构变化。已经注意到胶原纤维的渐进性溶解。肝细胞的变化表明这些细胞的合成和内吞活性增加。有人认为，在该过程中胶原的细胞外溶解是由胶原酶启动的，而随后它是在肝细胞分泌到细胞外空间的溶酶体酶的作用下发生的。
