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老年肌少症与高血压相关:系统评价和荟萃分析。

Geriatric sarcopenia is associated with hypertension: A systematic review and meta-analysis.

机构信息

Department of Geriatric Cardiovascular Diseases, Hebei General Hospital, Shijiazhuang, Hebei, China.

Graduate School of Hebei Medical University, Shijiazhuang, Hebei, China.

出版信息

J Clin Hypertens (Greenwich). 2023 Sep;25(9):808-816. doi: 10.1111/jch.14714. Epub 2023 Aug 18.

Abstract

This meta-analysis aimed to explore the potential relationship between senile sarcopenia and hypertension in older people. A comprehensive search was conducted in PubMed, Embase, Web of Science, and the Cochrane Library, up to November 2022. Ten studies comprising 14 804 participants were enrolled. The odds ratio (OR) and 95% confidence interval (CI) was pooled to evaluate the correlation between sarcopenia and hypertension in older people utilizing a random-effects model. Subgroup and sensitivity analyses were then carried out to explore the potential sources of heterogeneity. The results revealed a substantial correlation between sarcopenia and hypertension among older people (OR = 1.39, 95% CI: 1.15-1.67, p < .01). Further subgroup analysis revealed an association between sarcopenic obesity and hypertension (OR = 1.49, 95% CI: 1.37-1.62, p < .01). In conclusions, our findings highlighted a significant relationship between sarcopenia and hypertension among older people, with sarcopenic obesity amplifying this risk.

摘要

这项荟萃分析旨在探讨老年人中衰老性肌肉减少症与高血压之间的潜在关系。我们在 PubMed、Embase、Web of Science 和 Cochrane Library 中进行了全面检索,截至 2022 年 11 月。共纳入了 10 项包含 14804 名参与者的研究。使用随机效应模型,汇总了优势比(OR)和 95%置信区间(CI)来评估老年人中肌肉减少症与高血压之间的相关性。然后进行了亚组和敏感性分析,以探讨异质性的潜在来源。结果表明,老年人中肌肉减少症与高血压之间存在显著相关性(OR=1.39,95%CI:1.15-1.67,p<.01)。进一步的亚组分析表明,肌肉减少性肥胖与高血压之间存在关联(OR=1.49,95%CI:1.37-1.62,p<.01)。总之,我们的研究结果强调了老年人中肌肉减少症与高血压之间存在显著关系,而肌肉减少性肥胖则加剧了这种风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be34/10497027/5323029735a3/JCH-25-808-g002.jpg

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