1990年至2019年中国因高钠摄入导致的心房颤动/心房扑动所致死亡和残疾的估计及趋势

Estimates and trends in death and disability from atrial fibrillation/atrial flutter due to high sodium intake, China, 1990 to 2019.

作者信息

Yu Qingwen, Zhao Lijun, Tang Ting, Xin Ziyi, Feng Lanlan, Rao Xiyun, Shi Yongmin, Tong Xuhan, Hu Siqi, You Yao, Zhang Shenghui, Tang Jiake, Cheng Yongran, Zhang Xingwei, Wang Mingwei, Li Ximin

机构信息

Department of Cardiology, Affiliated Hospital of Hangzhou Normal University, Zhejiang Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences,Hangzhou Institute of Cardiovascular Diseases, Engineering Research Center of Mobile Health Management System & Ministry of Education, Hangzhou Normal University, Hangzhou, 310015, China.

Cancer Center, Department of Nuclear Medicine, Zhejiang Provincial People's Hospital(Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, China.

出版信息

BMC Cardiovasc Disord. 2025 Jan 25;25(1):49. doi: 10.1186/s12872-024-04449-y.

DOI:10.1186/s12872-024-04449-y

PMID:39863875

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11762119/

Abstract

OBJECTIVE

The effect of sodium intake on atrial fibrillation (AF)/atrial flutter (AFL), with respect to sex and age, has yet to be elucidated. This study aims to compare long-term trends in AF/AFL death and disability due to high sodium intake in China from 1990 to 2019.

METHODS

We utilized data from the Global Burden of Disease study to assess the mortality and disability burden of AF/AFL attributable to high sodium intake (> 5 g/d) in China from 1990 to 2019. Overtime trends and average annual percentage change (AAPC) were analyzed with adjustments for age, sex, period, and cohorts.

RESULTS

In 2019, the number of AF/AFL deaths and disability-adjusted life years attributable to high sodium intake were 4209.944 (95% UI: [1250.690-8718.238]) and 235484.586 (95% UI: [89136.783-428566.694]), with males comprising 44.81% and 51.95% of cases, respectively. The age-standardized mortality rates (ASMRs) and age-standardized disability rates (ASDRs) of AF/AFL attributable to high sodium intake exhibited downward trends from 1990 to 2019 in China. The AAPC was - 0.221(95% CI: -0.321-0.121)and - 0.631(95% CI: -0.816-0.446) for AF/AFL, respectively. An upward trend was observed in ASMRs for AF and AFL, attributable to high sodium intake due to high salt intake at ages 30-34, 35-39, and 40-44. With an increase in age, the AAPC for ASMRs increased correspondingly, and the AAPC for ASDRs exhibited a decreasing trend.

CONCLUSIONS

Our findings provide strong evidence that high sodium levels in China significantly affect standard ASMRs and ASDRs for AF and AFL. Notably, different patterns of change are identified across various age groups, emphasizing the pronounced effect of salt reduction on AF and AFL.

摘要

目的

钠摄入量对心房颤动（AF）/心房扑动（AFL）的影响，在性别和年龄方面，尚未阐明。本研究旨在比较1990年至2019年中国高钠摄入导致的AF/AFL死亡和残疾的长期趋势。

方法

我们利用全球疾病负担研究的数据，评估1990年至2019年中国高钠摄入（>5克/天）导致的AF/AFL的死亡率和残疾负担。分析了随时间的趋势和平均年度百分比变化（AAPC），并对年龄、性别、时期和队列进行了调整。

结果

2019年，高钠摄入导致的AF/AFL死亡人数和伤残调整生命年分别为4209.944（95%UI：[1250.690 - 8718.238]）和235484.586（95%UI：[89136.783 - 428566.694]），男性分别占病例的44.81%和51.95%。1990年至2019年，中国高钠摄入导致的AF/AFL的年龄标准化死亡率（ASMRs）和年龄标准化残疾率（ASDRs）呈下降趋势。AF/AFL的AAPC分别为-0.221（95%CI：-0.321 - 0.121）和-0.631（95%CI：-0.816 - 0.446）。在30 - 34岁、35 - 39岁和40 - 44岁因高盐摄入导致高钠摄入的AF和AFL的ASMRs中观察到上升趋势。随着年龄的增加，ASMRs的AAPC相应增加，ASDRs的AAPC呈下降趋势。