Martignago Damiano, da Silveira Falavigna Vítor, Coupland George, Conti Lucio
Dipartimento di Bioscienze, Università degli Studi di Milano, Milan, Italy.
Max Planck Institute for Plant Breeding Research, Cologne, Germany.
J Exp Bot. 2025 May 27;76(8):2081-2095. doi: 10.1093/jxb/eraf034.
Group A basic leucine zipper (bZIP) transcription factors play critical roles in abscisic acid (ABA) signaling and plant development. In Arabidopsis thaliana, these factors are defined by a highly conserved core bZIP domain, and four conserved domains throughout their length: three at the N-terminus (C1-C3) and a phosphorylatable C-terminal SAP motif located at the C4 domain. Initially, members such as ABI5 and ABFs were studied for their roles in ABA signaling during seed germination or stress responses. Later, a sub-clade of group A bZIPs, including FD, was found to play important roles in floral induction by interacting with the florigen FLOWERING LOCUS T (FT) at the shoot apical meristem. Recent research has expanded our understanding of these transcription factors by identifying intriguing parallels between those involved in ABA signaling and those promoting floral induction, and revealing dynamic interactions with FT and other phosphatidylethanolamine-binding proteins (PEBPs) such as TERMINAL FLOWER 1. Studies in crop plants and non-model species demonstrate broader roles, functions, and molecular targets of group A bZIPs. This review highlights common features of group A bZIPs and their post-translational regulation in enabling the activation of gene regulatory networks with important functions in plant development and stress responses.
A组碱性亮氨酸拉链（bZIP）转录因子在脱落酸（ABA）信号传导和植物发育中发挥关键作用。在拟南芥中，这些因子由一个高度保守的核心bZIP结构域以及贯穿其全长的四个保守结构域定义：三个位于N端（C1 - C3），一个可磷酸化的C端SAP基序位于C4结构域。最初，ABI5和ABFs等成员因其在种子萌发或应激反应期间ABA信号传导中的作用而受到研究。后来，发现包括FD在内的A组bZIPs的一个亚分支通过在茎尖分生组织与成花素FLOWERING LOCUS T（FT）相互作用，在花诱导中发挥重要作用。最近的研究通过确定参与ABA信号传导的因子与促进花诱导的因子之间有趣的相似之处，并揭示与FT和其他磷脂酰乙醇胺结合蛋白（PEBP）如TERMINAL FLOWER 1的动态相互作用，扩展了我们对这些转录因子的理解。对作物和非模式物种的研究表明A组bZIPs具有更广泛的作用、功能和分子靶点。本综述强调了A组bZIPs的共同特征及其翻译后调控，这些调控能够激活在植物发育和应激反应中具有重要功能的基因调控网络。
