Dias E-S, Freitas L-C, Miyazawa M, Nogueira D-A, Oliveira C-E, Pereira A-A, Hanemann J-A
School of Dentistry. Federal University of Alfenas Rua Gabriel Monteiro da Silva, 700. Centro 37130.001. Alfenas, Minas Gerais, Brazil
Med Oral Patol Oral Cir Bucal. 2025 Mar 1;30(2):e240-e246. doi: 10.4317/medoral.26886.
Paracoccidioidomycosis (PCM) is a systemic mycosis endemic and limited to Latin America. Brazil is responsible for more than 80% of diagnosed cases in the world. Since PCM is not a notifiable disease, there are still no accurate data on its incidence in Brazil. Vascular endothelial growth factor (VEGF) is considered the main vascular endothelial growth factor expressed in the process of angiogenesis, both under physiological and pathological conditions. To date, there are not studies in the literature that evaluated the expression of VEGF in oral PCM lesions. Therefore, the objective of this study was to evaluate the prevalence of oral lesions of PCM diagnosed from 1998 to 2020; to analyze the immunoexpression of VEGF in oral lesions of PCM; and to compare the VEGF immunostaining with the clinical and microscopic aspects of these lesions.
Clinical data of 98 cases of patients with oral PCM were evaluated. A total of 41 selected cases were quantitatively and qualitatively analysed by immunohistochemistry for VEGF.
Our results showed that oral PCM preferentially affects white males, with mean age of 50.2 years, and the gingiva and the alveolar ridge. It was not possible to correlate VEGF immunoexpression with clinical and microscopic variables.
Oral PCM is a relatively uncommon pathological condition and that, in our sample, the immunoexpression of VEGF was mild and observed in a reduced number of cases.
副球孢子菌病（PCM）是一种局限于拉丁美洲流行的系统性真菌病。巴西的确诊病例占全球的80%以上。由于PCM并非法定报告疾病，巴西仍没有关于其发病率的准确数据。血管内皮生长因子（VEGF）被认为是生理和病理条件下血管生成过程中表达的主要血管内皮生长因子。迄今为止，文献中尚无评估VEGF在口腔PCM病变中表达的研究。因此，本研究的目的是评估1998年至2020年诊断的口腔PCM病变的患病率；分析VEGF在口腔PCM病变中的免疫表达；并将VEGF免疫染色与这些病变的临床和微观特征进行比较。
评估98例口腔PCM患者的临床资料。通过免疫组织化学对41例选定病例进行VEGF的定量和定性分析。
我们的结果显示，口腔PCM优先影响白人男性，平均年龄为50.2岁，以及牙龈和牙槽嵴。无法将VEGF免疫表达与临床和微观变量相关联。
口腔PCM是一种相对罕见的病理状况；在我们的样本中，VEGF的免疫表达较轻，且仅在少数病例中观察到。
