Department of Clinic and Surgery, School of Dentistry, Federal University of Alfenas, Rua Gabriel Monteiro da Silva 700, Alfenas, MG, 37130-001, Brazil.
Department of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas, Alfenas, Brazil.
Mycopathologia. 2018 Oct;183(5):785-791. doi: 10.1007/s11046-018-0272-7. Epub 2018 May 23.
Paracoccidioidomycosis is a neglected tropical fungal infection with great predilection for adult men, indicating the participation of female hormone estrogen in preventing paracoccidioidomycosis development in women. Estrogen has an immunologic effect leading to polarization toward the Th2 immune response, which favors the disease evolution.
To evaluate estrogen and progesterone receptors in oral paracoccidioidomycosis lesions and to verify any association with tissue fungi counting in women and men.
Thirty-two cases of chronic oral paracoccidioidomycosis were included. Immunohistochemical analyses for anti-estrogen receptor-α, anti-progesterone receptor and anti-Paracoccidioides brasiliensis antibodies were performed. The differences between women and men and the relations among the immunomarkers for each gender were also evaluated.
A significant positive correlation was observed between estrogen receptor-α and the amount of fungi in women. In addition, estrogen receptor-α was mildly expressed in the inflammatory cells of female patients, while progesterone receptor was expressed in both genders, with similar expression between women and men. Moreover, fungi counting revealed no differences between genders.
Estrogen receptor-α was expressed only in women and showed a positive correlation with the amount of fungi in oral paracoccidioidomycosis, while progesterone receptor was observed in both genders and exhibited no correlation with estrogen receptor-α or fungi counting.
球孢子菌病是一种被忽视的热带真菌感染，对成年男性有很大的偏好，这表明女性激素雌激素在预防女性球孢子菌病发展中起作用。雌激素具有免疫作用，导致向 Th2 免疫反应极化，有利于疾病的发展。
评估口腔球孢子菌病病变中的雌激素和孕激素受体，并验证其与女性和男性组织真菌计数的任何关联。
纳入 32 例慢性口腔球孢子菌病患者。进行抗雌激素受体-α、抗孕激素受体和抗巴西副球孢子菌抗体的免疫组织化学分析。还评估了女性和男性之间的差异以及每个性别免疫标志物之间的关系。
在女性中，雌激素受体-α 与真菌数量之间存在显著正相关。此外，雌激素受体-α 在女性患者的炎症细胞中轻度表达，而孕激素受体在两性中均有表达，且女性和男性之间的表达相似。此外，真菌计数在两性之间没有差异。
仅在女性中表达雌激素受体-α，并与口腔球孢子菌病中的真菌数量呈正相关，而孕激素受体在两性中均有表达，与雌激素受体-α 或真菌计数无相关性。
