Hong Xinyang, Chen Tongkai, Liu Yunyun, Li Jun, Huang Dongqing, Ye Kaiyu, Liao Wanchen, Wang Yulin, Liu Mengling, Luan Ping
Department of Alzheimer's Disease Clinical Research Center, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510317, China.
Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Ageing Res Rev. 2025 Mar;105:102669. doi: 10.1016/j.arr.2025.102669. Epub 2025 Jan 27.
Alzheimer's disease (AD), an age-related neurodegenerative disease, brings huge damage to the society, to the whole family and even to the patient himself. However, until now, the etiological factor of AD is still unknown and there is no effective treatment for it. Massive deposition of amyloid-beta peptide(Aβ) and hyperphosphorylation of Tau proteins are acknowledged pathological features of AD. Recent studies have revealed that neuroinflammation plays a pivotal role in the pathology of AD. With the rise of nanomaterials in the biomedical field, researchers are exploring how the unique properties of these materials can be leveraged to develop effective treatments for AD. This article has summarized the influence of neuroinflammation in AD, the design of nanoplatforms, and the current research status and inadequacy of nanomaterials in improving neuroinflammation in AD.
阿尔茨海默病（AD）是一种与年龄相关的神经退行性疾病，给社会、整个家庭乃至患者本人都带来了巨大损害。然而，直到现在，AD的病因仍然不明，且尚无有效的治疗方法。β-淀粉样肽（Aβ）的大量沉积和Tau蛋白的过度磷酸化是公认的AD病理特征。最近的研究表明，神经炎症在AD的病理过程中起关键作用。随着纳米材料在生物医学领域的兴起，研究人员正在探索如何利用这些材料的独特性质来开发针对AD的有效治疗方法。本文总结了神经炎症在AD中的影响、纳米平台的设计，以及纳米材料在改善AD神经炎症方面的研究现状和不足。
