Alkandari Meshari, Barai Paritosh, Atia Gamal Abdel Nasser, Mohamed Sara Z, Ghobashy Mohamed Mohamady, Shalaby Hany K, Foda Tarek, Rabbee Muhammad Fazle, Mallick Samir, Barai Hasi Rani, Hossain Mohammad Nazir
Department of Dentistry, Rumaithiya Polyclinic, Ministry of Health, Rumaithiya, Kuwait.
Department of Marine Biotechnology & Genetic Engineering, Bangabandhu Sheikh Mujibur Rahman Maritime University, Dhaka, Bangladesh.
Biotechnol J. 2025 Jan;20(1):e202400653. doi: 10.1002/biot.202400653.
Due to their superior physicochemical features, chitosan thermosensitive hydrogels are multipurpose platforms that are frequently used in the biomedical industry. Many investigations have been conducted recently to modify their pore dimensions, expansion, biodegradability, stimulus-reaction characteristics, and other characteristics in order to better tailor them to the complex craniofacial tissues. They have been the focus of various studies that have attempted to load biological cargos for therapeutic and regenerative uses in the oro-facial tissues. This article assesses the utility and advancements of chitosan thermosensitive hydrogel-based pharmaceutical delivery devices for the management of craniofacial disorders such as dental caries, endodontic diseases, periodontitis, temporomandibular disorders, mucosal diseases, cancer, and so forth.
由于其优异的物理化学特性，壳聚糖热敏水凝胶是多功能平台，在生物医学行业中经常使用。最近进行了许多研究，以改变其孔径、膨胀性、生物降解性、刺激反应特性和其他特性，以便更好地使其适用于复杂的颅面组织。它们一直是各种研究的焦点，这些研究试图负载生物货物用于口腔面部组织的治疗和再生用途。本文评估了基于壳聚糖热敏水凝胶的药物递送装置在治疗龋齿、牙髓病、牙周炎、颞下颌疾病、黏膜疾病、癌症等颅面疾病方面的效用和进展。
