Chen Tzu-Pai, Hsu Heng-Jui
Department of Otolaryngology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Ear Nose Throat J. 2025 Jan 26:1455613251316254. doi: 10.1177/01455613251316254.
NUT carcinoma is a rare, aggressive malignancy characterized by chromosomal rearrangements involving the NUTM1 gene. We present the case of a 47-year-old male with a history of hypertension, diagnosed with NUT carcinoma originating in the ethmoid sinus and accompanied by extensive neck metastases. The patient underwent a left modified radical neck dissection and endoscopic nasal tumor excision, followed by concurrent chemoradiotherapy. Pathological examination confirmed NUT carcinoma with metastatic cancer cells in 41 out of 72 lymph nodes of left neck, along with extranodal extension. The patient remained alive at the 4-month follow-up. This case highlights the importance of early identification and including NUT carcinoma in the differential diagnosis to optimize treatment outcomes.
NUT癌是一种罕见的侵袭性恶性肿瘤，其特征是涉及NUTM1基因的染色体重排。我们报告一例47岁男性患者，有高血压病史，诊断为起源于筛窦的NUT癌，并伴有广泛的颈部转移。患者接受了左侧改良根治性颈清扫术和鼻内镜肿瘤切除术，随后进行同步放化疗。病理检查证实为NUT癌，左侧颈部72个淋巴结中有41个存在转移癌细胞，并伴有结外侵犯。患者在4个月的随访时仍存活。该病例强调了早期识别以及将NUT癌纳入鉴别诊断以优化治疗结果的重要性。
