Chatterjee Priti, Nangia Anita, Osama Md Ali, Sharma M C, Kolluru Kartik, Kumar Sunil
Department of Pathology, Lady Hardinge Medical College, New Delhi, India.
Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
Indian J Surg Oncol. 2025 Apr;16(2):702-707. doi: 10.1007/s13193-024-01907-z. Epub 2024 Feb 27.
Nuclear protein in testis (NUT) carcinoma is a highly aggressive and poorly differentiated carcinoma, defined by presence of NUT rearrangements in the (NUT midline carcinoma family member 1) gene. This tumor has a predilection for midline and paramidline structures of the upper aerodigestive tract and mediastinum and has a devastating clinical course, thus an early diagnosis is indispensable. However, due to its low incidence, this is often misdiagnosed by the clinicians and pathologists. Here, we report a case of NUT midline carcinoma of the nasal cavity in a 53-year-old man who presented with chief complaints of nasal discharge and obstruction, accompanied by blurring of vision and facial swelling. The present case report reviews the clinical characteristics, histopathological diagnosis of NUT carcinoma, highlighting the morphological and immunohistochemical findings and the pathological approach to sinonasal undifferentiated tumors encountered.
睾丸核蛋白（NUT）癌是一种侵袭性很强且分化程度低的癌，由BRD4-NUT（含溴结构域蛋白4-睾丸核蛋白）基因重排所定义。该肿瘤好发于上消化道和纵隔的中线及旁中线结构，临床病程凶险，因此早期诊断必不可少。然而，由于其发病率低，临床医生和病理学家常常误诊。在此，我们报告一例53岁男性鼻腔NUT中线癌病例，该患者主要症状为鼻分泌物增多和鼻塞，伴有视力模糊和面部肿胀。本病例报告回顾了NUT癌的临床特征、组织病理学诊断，重点介绍了形态学和免疫组化结果以及对鼻窦未分化肿瘤的病理诊断方法。
