Helmers J H, van Leeuwen L
Acta Anaesthesiol Belg. 1979 Dec;30(4):265-72.
Forty seven patients received either 4 mg or 10 mg domperidone I.V. in a double blind study after they had vomited postoperatively. The patients were then observed for six hours. If necessary, the same dose of domperidone was repeated double blind but not during the first hour. When the two groups were compared there was little difference between them for the first half hour after the initial dose, thereafter both the frequency and severity of vomiting was reduced in the 10 mg group. Also fewer patients in the 10 mg group needed a second injection. These differences were statistically significant (p less than 0.05).
在一项双盲研究中，47例患者术后呕吐后静脉注射4毫克或10毫克多潘立酮。然后对患者观察6小时。如有必要，双盲重复给予相同剂量的多潘立酮，但不在第1小时内。两组比较时，初始剂量后的前半小时两组之间差异不大，此后10毫克组呕吐的频率和严重程度均降低。10毫克组中需要第二次注射的患者也较少。这些差异具有统计学意义（p小于0.05）。
