Sukaina Mahnoor, Waheed Marium, Rehman Shafi, Hasibuzzaman Md Al, Meghani Rabab
Department of Internal Medicine, Karachi Medical and Dental College, Karachi 75270, Pakistan.
Department of Histopathology, Khyber Medical University, Peshawar, 25000, Pakistan.
World J Cardiol. 2025 Jan 26;17(1):99933. doi: 10.4330/wjc.v17.i1.99933.
Atrial fibrillation (AF)/atrial flutter (AFL) is the most common sustained cardiac arrhythmia. The known risk factors for developing AF/AFL include age, structural heart disease, hypertension, diabetes mellitus, or hyperthyroidism. This study aims to attribute the trends in AF/AFL-related mortalities over the past two decades 1999-2020 concerning race and sex and disparity among them. To the best of our knowledge, this is the first study that estimates the trends and mortality due to AF/AFL from 1999-2020 in older adults in the United States. In this 21-year analysis of mortality data, we found a constant increase in mortality rates due to AF/AFL in older adults. From 1999 to 2020, the overall mortality in older adults aged 65 and above, regardless of sex and race, is found to be almost doubled about a 50.2% increase in the number of deaths due to AF/AFL. Furthermore, other confounding risk factors such has obesity, prior myocardial infarction, inflammation, hypertension, birth weight, diabetes mellitus, hyperthyroidism, hormone replacement therapy in menopausal women increases the risk in the occurrence or recurrent occurrence of AF.
心房颤动（AF）/心房扑动（AFL）是最常见的持续性心律失常。已知的发生AF/AFL的风险因素包括年龄、结构性心脏病、高血压、糖尿病或甲状腺功能亢进。本研究旨在分析1999年至2020年这二十年间与AF/AFL相关的死亡率在种族和性别方面的趋势以及它们之间的差异。据我们所知，这是第一项评估1999年至2020年美国老年人中AF/AFL导致的趋势和死亡率的研究。在这项长达21年的死亡率数据分析中，我们发现老年人中因AF/AFL导致的死亡率持续上升。从1999年到2020年，65岁及以上老年人的总体死亡率，无论性别和种族，因AF/AFL导致的死亡人数增加了约50.2%，几乎翻倍。此外，其他混杂风险因素，如肥胖、既往心肌梗死、炎症、高血压、出生体重、糖尿病、甲状腺功能亢进、绝经后女性的激素替代疗法，都会增加AF发生或复发的风险。
