Ahmed Shahzaib, Ahmad Shoaib, Ashraf Hamza, Ahmad Eeman, Akram Umar, Mallick Abbas H, Ullah Irfan, Ahmed Raheel, Alraies Chadi, Fonarow Gregg C
Department of Medicine Fatima Memorial Hospital College of Medicine and Dentistry Lahore Pakistan.
St. Joseph Hospital and Medical Center Phoenix Arizona USA.
J Arrhythm. 2025 May 22;41(3):e70096. doi: 10.1002/joa3.70096. eCollection 2025 Jun.
Thyroid gland disorders are a known risk factor for atrial fibrillation and flutter (AF/AFL). Despite being a well-established risk factor, most studies have primarily examined prevalence, comorbidities, and treatment patterns with little to no research on mortality trends for this association. Objective: We aimed to analyze the trends in AF/AFL-related mortality in patients with thyroid gland disorders.
Age-adjusted mortality rates and crude rates per 100,000 population from 1999 to 2020 using the CDC WONDER database. Annual percent changes and their averages were calculated via Joinpoint regression. AF/AFL-related mortality trends in patients with thyroid disorders were compared with those in the general population using pairwise comparison.
In the study period, a total of 7187 AF/AFL-related deaths were observed in individuals diagnosed with thyroid gland disorders. The age-adjusted mortality rates increased throughout the study period. The mortality rates in females remained consistently higher than those in males. Mortality rates did not vary substantially across regions (South: 0.09; Northeast: 0.09; Midwest: 0.10; West: 0.11). Furthermore, the annual percent change in females and South with thyroid disorders differed significantly from the general population. The states with the highest mortality rates were Oregon, Wyoming, and Nebraska. The mortality rates remained higher in nonmetropolitan regions (0.11) than in metropolitan regions (0.09).
AF/AFL-related mortality trends associated with thyroid disorders increased from 1999 to 2020. Policies that target vulnerable populations and regions may be beneficial in mitigating the increasing AF/AFL-related mortality associated with disorders of the thyroid gland.
甲状腺疾病是心房颤动和心房扑动（AF/AFL）的已知危险因素。尽管这是一个已确立的危险因素，但大多数研究主要关注患病率、合并症和治疗模式，而对这种关联的死亡率趋势几乎没有研究。目的：我们旨在分析甲状腺疾病患者中与AF/AFL相关的死亡率趋势。
使用疾病控制与预防中心（CDC）的WONDER数据库计算1999年至2020年每10万人口的年龄调整死亡率和粗死亡率。通过Joinpoint回归计算年度百分比变化及其平均值。使用成对比较将甲状腺疾病患者中与AF/AFL相关的死亡率趋势与普通人群的趋势进行比较。
在研究期间，在被诊断患有甲状腺疾病的个体中总共观察到7187例与AF/AFL相关的死亡。在整个研究期间，年龄调整死亡率有所上升。女性的死亡率一直高于男性。各地区的死亡率没有显著差异（南部：0.09；东北部：0.09；中西部：0.10；西部：0.11）。此外，患有甲状腺疾病的女性和南部地区的年度百分比变化与普通人群有显著差异。死亡率最高的州是俄勒冈州、怀俄明州和内布拉斯加州。非大都市地区的死亡率（0.11）仍然高于大都市地区（0.09）。
1999年至2020年，与甲状腺疾病相关的AF/AFL死亡率趋势有所上升。针对弱势群体和地区的政策可能有助于降低与甲状腺疾病相关的AF/AFL死亡率上升。
