Albahar Abdullah, Sarmiti Rana, Hossienzadeh Hamid, Houshmand Massoud
Department of Surgery, Sheikh Jaber Al Ahmed Al Jaber Al Sabah Hospital, Kuwait City, KWT.
Genetics Department, Al Soor Clinic, Kuwait City, KWT.
Cureus. 2024 Dec 27;16(12):e76477. doi: 10.7759/cureus.76477. eCollection 2024 Dec.
Laryngeal squamous cell cancer (LSCC) is one of the most common head and neck cancers in which genetic factors play an important role in its occurrence. This study investigated the association of and gene polymorphisms with the risk of LSCC. polymorphisms including rs712, rs61764370, rs8720, and rs9266, as well as NRAS rs14804, were compared in the patient group (n=120) and the control group (n=100). The Sanger sequencing method was used to identify these polymorphisms. The results showed that rs8720 is associated with an increased risk of LSCC; consequently, those with the CT genotype were at a higher risk than those with the CC genotype. Also, the CC genotype had a protective effect on rs14804 polymorphism of the gene. These findings show that some and polymorphisms can be used as diagnostic and prognostic biomarkers in LSCC, and their accurate identification by Sanger sequencing is of great importance in research related to cancer genetics.
喉鳞状细胞癌（LSCC）是最常见的头颈癌之一，其中遗传因素在其发生中起重要作用。本研究调查了[基因名称]和NRAS基因多态性与LSCC风险的关联。在患者组（n = 120）和对照组（n = 100）中比较了[基因名称]的rs712、rs61764370、rs8720和rs9266多态性以及NRAS rs14804。采用桑格测序法鉴定这些多态性。结果表明，[基因名称] rs8720与LSCC风险增加相关；因此，CT基因型者比CC基因型者风险更高。此外，CC基因型对NRAS基因的rs14804多态性具有保护作用。这些发现表明，一些[基因名称]和NRAS多态性可作为LSCC的诊断和预后生物标志物，通过桑格测序对其进行准确鉴定在癌症遗传学相关研究中具有重要意义。
