Charatcharoenwitthaya Kridh, Suntrapiwat Kajorn, Wongtrakul Wasit
International Demonstration School, Mahidol University, Nakhon Pathom, THA.
Pulmonary Diseases and Critical Care Medicine, Buddhachinaraj Hospital, Phitsanulok, THA.
Cureus. 2024 Dec 26;16(12):e76397. doi: 10.7759/cureus.76397. eCollection 2024 Dec.
Recent research suggests that tuberculosis (TB) may pose a potential risk factor for osteoporosis, although the available evidence remains limited. This study aimed to comprehensively assess osteoporosis risk in TB patients through systematic review and meta-analysis methodology. Two investigators independently conducted a literature search using the Medical Literature Analysis and Retrieval System Online (MEDLINE) and Excerpta Medica Database (EMBASE) databases up to April 2024. Eligible longitudinal cohort studies had to evaluate the impact of active or a history of TB on the risk of osteoporosis and/or osteoporotic fractures. Point estimates and standard errors from each eligible study were pooled using DerSimonian and Laird's generic inverse variance method. Of 2,062 articles (1,765 from EMBASE and 297 from MEDLINE) reviewed, three retrospective cohort studies, comprising a total of 531,624 participants (174,726 patients with TB and 356,898 participants without TB), met the eligibility criteria and were included in the meta-analysis. The pooled analysis of three studies revealed an increased risk of osteoporosis among TB patients, with a pooled hazard ratio of 1.40 (95% CI, 1.26 - 1.57; = 54%). The pooled analysis indicated that populations with TB also had a higher risk of osteoporotic fractures than populations without TB, with a pooled hazard ratio of 1.65 (95% CI, 1.26 - 2.15; = 71%). Our systematic review and meta-analysis demonstrated a significantly increased risk of osteoporosis and osteoporotic fractures in patients with TB.
近期研究表明，结核病（TB）可能是骨质疏松症的一个潜在风险因素，尽管现有证据仍然有限。本研究旨在通过系统评价和荟萃分析方法全面评估结核病患者的骨质疏松症风险。两名研究者独立使用医学文献分析和检索系统在线数据库（MEDLINE）和医学文摘数据库（EMBASE）进行文献检索，检索截至2024年4月。符合条件的纵向队列研究必须评估活动性结核病或结核病病史对骨质疏松症和/或骨质疏松性骨折风险的影响。使用DerSimonian和Laird的通用逆方差方法汇总每个符合条件研究的点估计值和标准误差。在审查的2062篇文章（1765篇来自EMBASE，297篇来自MEDLINE）中，三项回顾性队列研究符合纳入标准并被纳入荟萃分析，这些研究共有531,624名参与者（174,726名结核病患者和356,898名非结核病参与者）。三项研究的汇总分析显示，结核病患者骨质疏松症风险增加，汇总风险比为1.40（95%CI，1.26 - 1.57；P = 54%）。汇总分析表明，结核病患者发生骨质疏松性骨折的风险也高于非结核病患者，汇总风险比为1.65（95%CI，1.26 - 2.15；P = 71%）。我们的系统评价和荟萃分析表明，结核病患者骨质疏松症和骨质疏松性骨折的风险显著增加。
