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维生素B6对骨质疏松性骨折的影响。

Effect of Vitamin B6 on Osteoporosis Fracture.

作者信息

Welan Rahmani

机构信息

Department of Nutritional Science, Faculty of Medicine, Universitas Andalas, Padang, Indonesia.

出版信息

J Bone Metab. 2023 May;30(2):141-147. doi: 10.11005/jbm.2023.30.2.141. Epub 2023 May 31.

DOI:10.11005/jbm.2023.30.2.141
PMID:37449347
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10346000/
Abstract

Osteoporosis is a medical condition that causes bones to become weak and brittle, making them more likely to break or fracture. This condition occurs when the body loses too much bone, makes too little bone, or both. Bones are living tissues that are constantly being broken down and rebuilt. However, as we age, this process slows down, and our bodies may be unable to replace bone as quickly as it is broken down. This can lead to a loss of bone density, making bones weaker and more prone to fracture. Unfortunately, osteoporosis often has no symptoms until a bone is broken, so taking steps to prevent this condition is essential. This may include getting enough calcium and vitamin D, engaging in weight-bearing exercise, quitting smoking, limiting alcohol intake, and taking medication if prescribed by a doctor. Vitamin B6, also known as pyridoxine, is a water-soluble vitamin that plays a vital role in various bodily functions. It is part of the B-vitamin complex and is essential for metabolizing proteins, carbohydrates, and fats. Vitamin B6 produces neurotransmitters such as serotonin, which helps regulate mood, and dopamine, which is involved in motivation and reward. Several previous studies have found that women with higher intakes of vitamin B6 have higher bone mineral density (BMD) of the hips and spine than women with lower intakes. Another study found that men and women with higher blood levels of vitamin B6 had higher BMD in the hips and spine.

摘要

骨质疏松症是一种使骨骼变得脆弱易碎、更易折断或骨折的病症。当身体流失过多骨质、生成过少骨质或二者兼而有之时,就会出现这种情况。骨骼是不断进行分解和重建的活组织。然而,随着年龄增长,这个过程会放缓,我们的身体可能无法像分解骨骼那样快速地替换骨骼。这会导致骨密度降低,使骨骼更脆弱且更易骨折。不幸的是,骨质疏松症通常在骨骼骨折之前没有症状,所以采取措施预防这种病症至关重要。这可能包括摄入足够的钙和维生素D、进行负重锻炼、戒烟、限制酒精摄入,以及按医生处方服药。维生素B6,也称为吡哆醇,是一种水溶性维生素,在各种身体功能中起着至关重要的作用。它是B族维生素复合物的一部分,对于蛋白质、碳水化合物和脂肪的代谢必不可少。维生素B6能产生血清素等神经递质,血清素有助于调节情绪,还有多巴胺,它与动机和奖赏有关。此前的多项研究发现,维生素B6摄入量较高的女性,其髋部和脊柱的骨矿物质密度(BMD)高于摄入量较低的女性。另一项研究发现,血液中维生素B6水平较高的男性和女性,其髋部和脊柱的骨矿物质密度也较高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3079/10346000/575ae4442be2/jbm-2023-30-2-141f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3079/10346000/575ae4442be2/jbm-2023-30-2-141f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3079/10346000/575ae4442be2/jbm-2023-30-2-141f1.jpg

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结核病与骨质疏松症之间的关联:一项系统评价与荟萃分析
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Relationship of Low Vitamin B6 Status with Sarcopenia, Frailty, and Mortality: A Narrative Review.维生素 B6 水平低下与肌肉减少症、虚弱和死亡率的关系:叙事性综述。
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