Gergoudis Maria, Laubach Logan, Lee Glenn E, Donowitz Jeffrey R
Department of Orthopaedic Surgery, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.
Department of Orthopaedic Surgery, University of California San Francisco-Fresno, Fresno, California, USA.
Case Rep Infect Dis. 2025 Jan 18;2025:5117572. doi: 10.1155/crdi/5117572. eCollection 2025.
We present the case of a fully vaccinated 39-year-old male with no pertinent past medical history who initially presented with De Quervain's tenosynovitis which was successfully treated with a corticosteroid injection. His symptoms recurred during a COVID-19 infection, which was treated with a repeat corticosteroid injection. Symptoms recurred during an influenza infection and were subsequently treated with a first dorsal compartment release. The etiology of De Quervain's tenosynovitis remains unclear. It has classically been categorized as a noninflammatory degenerative process, but recent evidence suggests a possible inflammatory connection. Here, we present a case of recurrent De Quervain's tenosynovitis exacerbated by two distinct viral infections. We hypothesize that viral-induced systemic inflammation led to localized recurrence of inflammation within the tendon sheath. Further studies including cytokine analysis and inflammatory markers are needed to advance this hypothesis.
我们报告一例39岁的男性病例，该患者已完成全程疫苗接种，无相关既往病史，最初表现为桡骨茎突狭窄性腱鞘炎，经皮质类固醇注射治疗成功。在新冠病毒感染期间症状复发，再次注射皮质类固醇进行治疗。在流感感染期间症状再次出现，随后接受了第一背侧腱鞘松解术。桡骨茎突狭窄性腱鞘炎的病因尚不清楚。传统上它被归类为非炎性退行性过程，但最近的证据表明可能存在炎症关联。在此，我们报告一例由两种不同病毒感染加重的复发性桡骨茎突狭窄性腱鞘炎病例。我们推测病毒诱导的全身炎症导致腱鞘内炎症局部复发。需要进一步的研究，包括细胞因子分析和炎症标志物检测来推进这一假说。
