Auger Samuel, Mishra Vasudha, Singh Alka, Miao Yuxuan, Agrawal Nishant, Izumchenko Evgeny
Section of Otolaryngology-Head and Neck Surgery, University of Chicago, Chicago, IL 60637, USA.
Department of Medicine, Section of Hematology and Oncology, University of Chicago, Chicago, IL 60637, USA.
Acad Oncol. 2024;1(2). doi: 10.20935/acadonco7456. Epub 2024 Dec 19.
Squamous cell carcinoma (SCC) is the most common malignancy of the head and neck. Stagnating survival rates in recent decades, despite advances in the treatment paradigms, surveillance technologies, and multidisciplinary care, leave clinicians with a need for better options for screening, risk-stratifying, and monitoring patients. A growing proportion of patients with HPV-associated SCC have improved outcomes but continue to have a heterogenous response to treatment. Advances in the platforms and assays measuring circulating tumor DNA offer an opportunity to monitor disease status at the molecular level for both virally mediated and traditional risk-factor-driven SCC of the head and neck. This overview will discuss experimental, clinically used, and commercially available liquid biopsy platforms and their recent applications in patients with head and neck SCC malignancies.
鳞状细胞癌（SCC）是头颈部最常见的恶性肿瘤。尽管在治疗模式、监测技术和多学科护理方面取得了进展，但近几十年来生存率停滞不前，这使得临床医生需要更好的方法来对患者进行筛查、风险分层和监测。越来越多的人乳头瘤病毒（HPV）相关SCC患者的治疗效果有所改善，但对治疗的反应仍然存在异质性。测量循环肿瘤DNA的平台和检测方法的进展为在分子水平上监测头颈部病毒介导和传统风险因素驱动的SCC的疾病状态提供了机会。本综述将讨论实验性、临床应用和商业可用的液体活检平台及其在头颈部SCC恶性肿瘤患者中的最新应用。
