Qayed Emad
Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, GA 30303, United States.
World J Clin Oncol. 2025 Jan 24;16(1):100943. doi: 10.5306/wjco.v16.i1.100943.
Gastric cancer (GC) and gastroesophageal junction cancer (GEJC) represent a significant burden globally, with complications such as overt bleeding (OB) further exacerbating patient outcomes. A recent study by Yao evaluated the effectiveness and safety of systematic treatment in GC/GEJC patients presenting with OB. Using propensity score matching, the study balanced the comparison groups to investigate overall survival and treatment-related adverse events. The study's findings emphasize that systematic therapy can be safe and effective and contribute to the ongoing debate about the management of advanced GC/GEJC with OB, highlighting the complexities of treatment decisions in these high-risk patients.
胃癌（GC）和胃食管交界癌（GEJC）在全球范围内构成了重大负担，诸如显性出血（OB）等并发症进一步加剧了患者的病情。姚最近的一项研究评估了系统性治疗在出现OB的GC/GEJC患者中的有效性和安全性。该研究采用倾向评分匹配法，平衡了比较组以调查总生存期和治疗相关不良事件。研究结果强调，系统性治疗可以是安全有效的，并有助于正在进行的关于晚期GC/GEJC合并OB的管理的辩论，突出了这些高危患者治疗决策的复杂性。
