Zhang Fushen, Xu Weiye, Deng Zejun, Huang Jufang
Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha, China.
School of Materials Science and Engineering, State Key Laboratory of Powder Metallurgy, Central South University, Changsha, China.
Front Med (Lausanne). 2025 Jan 10;11:1487981. doi: 10.3389/fmed.2024.1487981. eCollection 2024.
Electrochemical biosensors can provide an economical, accurate and rapid method for early screening of disease biomarkers in clinical medicine due to their high sensitivity, selectivity, portability, low cost and easy manufacturing, and multiplexing capability. Tear, a fluid naturally secreted by the human body, is not only easily accessible but also contains a great deal of biological information. However, no bibliometric studies focus on applying electrochemical sensors in tear/eye diseases. Therefore, we utilized VOSviewer and CiteSpace, to perform a detailed bibliometric analysis of 114 papers in the field of research on the application of tear in electrochemical biosensors screened from Web of Science with the combination of Scimago Graphica and Microsoft Excel for visualization to show the current research hotspots and future trends. The results show that the research in this field started in 2008 and experienced an emerging period in recent years. Researchers from China and the United States mainly contributed to the thriving research areas, with 41 and 29 articles published, respectively. Joseph Wang from the University of California San Diego is the most influential author in the field, and is the journal with the most published research and the most cited journal. The highest appearance keywords were "biosensor" and "tear glucose," while the most recent booming keywords "diagnosis" and "in-vivo" were. In conclusion, this study elucidates current trends, hotspots, and emerging frontiers, and provides future biomarkers of ocular and systemic diseases by electrochemical sensors in tear with new ideas and opinions.
由于具有高灵敏度、选择性、便携性、低成本、易于制造以及多重检测能力，电化学生物传感器能够为临床医学中疾病生物标志物的早期筛查提供一种经济、准确且快速的方法。眼泪是人体自然分泌的一种液体，不仅易于获取，还包含大量生物信息。然而，尚无文献计量学研究聚焦于将电化学传感器应用于泪液/眼部疾病。因此，我们利用VOSviewer和CiteSpace，对从Web of Science筛选出的114篇关于泪液在电化学生物传感器中应用的研究领域论文进行了详细的文献计量分析，并结合Scimago Graphica和Microsoft Excel进行可视化处理，以展示当前的研究热点和未来趋势。结果表明，该领域的研究始于2008年，近年来经历了一个兴起阶段。中国和美国的研究人员对该领域蓬勃发展贡献最大，分别发表了41篇和29篇文章。加利福尼亚大学圣地亚哥分校的约瑟夫·王是该领域最具影响力的作者， 是发表研究最多且被引用最多的期刊。出现频率最高的关键词是“生物传感器”和“泪液葡萄糖”，而最近兴起的关键词是“诊断”和“体内”。总之，本研究阐明了当前的趋势、热点和新兴前沿，并通过泪液中的电化学传感器为眼部和全身性疾病的未来生物标志物提供了新的思路和观点。
