Al-Timimi Noor Mohammed, Baraaj Abed Hassan
Uniuniversity of Baghdad.
Probl Endokrinol (Mosk). 2024 Mar 7;70(6):62-66. doi: 10.14341/probl13410.
KI-67 (MKI-67 in humans) is a protein able to bind to DNA which contributes to cell growth and cell proliferation. KI-67 is currently considered as a biomarker that is widely utilized as prognostic indicator for evaluating cell proliferation, diagnosing diseases, and conducting research. Several different kinds of cancer have high Ki-67 expression, which simplifying the choice of treatment for individuals with various cancer types.
The objective was to evaluate the expression of KI67 in patients suffering papillary thyroid cancer (PTC) also the association between patients age and gender and KI67 expression.
To undertake an in-depth investigation of KI67 in malignant and normal tissues, we used thyroid tissue sections to analyze KI67 expression in 70 samples, 50 different PTC (44 female and 6 male), and 20 normal types (10 for each gender). Each group's average age is between 20 and 60.
The analysis of the data revealed a substantial difference in the expression of ki67 between the patients and control groups. Ki67 expression and either gender or age did not significantly correlate.
This study suggest that KI67 may be a crucial marker for assessing the aggressiveness of tumors and inflammatory diseases.
KI-67（人类中的MKI-67）是一种能够与DNA结合的蛋白质，它有助于细胞生长和增殖。KI-67目前被认为是一种生物标志物，广泛用作评估细胞增殖、诊断疾病和开展研究的预后指标。几种不同类型的癌症具有高KI-67表达，这简化了针对不同癌症类型个体的治疗选择。
目的是评估KI67在甲状腺乳头状癌（PTC）患者中的表达，以及患者年龄、性别与KI67表达之间的关联。
为了深入研究KI67在恶性和正常组织中的情况，我们使用甲状腺组织切片分析了70个样本中KI67的表达，其中50个为不同的PTC样本（44例女性和6例男性），20个为正常样本（每种性别各10个）。每组的平均年龄在20至60岁之间。
数据分析显示，患者组和对照组之间ki67的表达存在显著差异。KI67表达与性别或年龄均无显著相关性。
本研究表明，KI67可能是评估肿瘤和炎症性疾病侵袭性的关键标志物。
