- Hospital Alemão Oswaldo Cruz, Center for Robotic Surgery - São Paulo - SP - Brasil.
- Faculdade de Medicina da Universidade de São Paulo (FMUSP), Urologia - São Paulo - SP - Brasil.
Rev Col Bras Cir. 2022 Jul 1;49:e20223200. doi: 10.1590/0100-6991e-20223200-en. eCollection 2022.
specialists have an urge for biomarkers that can discriminate indolent prostate cancer from aggressive tumors. Ki67 is a proliferation marker, and its expression is associated with the aggressiveness of several cancers.
analyze the expression of Ki67 in prostate cancer samples correlating with the aggressiveness of the disease.
Ki67 mRNA levels were determined utilizing data from a TCGA cohort (Tumor(n)=492 and control(n)=52). The protein expression was determined on 94 biopsies from patients by immunohistochemical assay.
in mRNA, the Ki67 upregulation is associated with cancer tissue (p<0.0001) and worst disease-free survival (p=0.035). The protein upregulation is associated with increase of the ISUP score (p<0.0001), cancer stage (p=0.05), biochemical recurrence (p=0.0006) and metastasis (p<0.0001). We also show a positive correlation between Ki67 expression and ISUP score (r=0.5112, p<0.0001) and disease risk stratification (r=0.3388, p=0.0009). Ki67 expression is a factor independently associated with biochemical recurrence (p=0.002) and metastasis (p<0.0001). Finally, the patients with high Ki67expression shows better survival regarding biochemical recurrence (p=0.008) and metastasis (p=0.056). Patients with high Ki67 expression are 2.62 times more likely to develop biochemical recurrence (p=0.036).
Ki67 upregulation is associated with prostate cancer aggressiveness.
专家们渴望找到能够区分惰性前列腺癌和侵袭性肿瘤的生物标志物。Ki67 是一种增殖标志物，其表达与多种癌症的侵袭性相关。
分析 Ki67 在前列腺癌样本中的表达与疾病侵袭性的相关性。
利用 TCGA 队列（肿瘤(n)=492，对照(n)=52）的数据来测定 Ki67 mRNA 水平。通过免疫组织化学检测 94 例患者的活检标本中 Ki67 蛋白的表达。
在 mRNA 水平上，Ki67 的上调与癌症组织（p<0.0001）和最差无病生存率（p=0.035）相关。蛋白上调与 ISUP 评分增加（p<0.0001）、癌症分期（p=0.05）、生化复发（p=0.0006）和转移（p<0.0001）相关。我们还显示 Ki67 表达与 ISUP 评分（r=0.5112，p<0.0001）和疾病风险分层（r=0.3388，p=0.0009）呈正相关。Ki67 表达是生化复发（p=0.002）和转移（p<0.0001）的独立相关因素。最后，Ki67 高表达的患者在生化复发（p=0.008）和转移（p=0.056）方面的生存情况更好。Ki67 高表达的患者发生生化复发的风险是 Ki67 低表达患者的 2.62 倍（p=0.036）。
Ki67 的上调与前列腺癌的侵袭性相关。
