Giamarellou H, Koratzanis G, Kanellakopoulou K, Daikos G K
Chemioterapia. 1985 Feb;4(1):43-6.
In 1983 an increase in the resistance rate of cefotaxime against Enterobacter cloacae strains was observed in "Laikos General" hospital, that reached 59.3% in the 2nd half of the same year. All strains resistant to cefotaxime were found resistant to cefamandole, moxalactam and ceftriaxone while 61.8% were also resistant to amikacin. Urine represented the main source of isolation, particularly from the catheterized patient of the Renal Transplantation Unit in whom cefuroxime was mostly over used. Multiresistant strains were virulent since 5 patients died of septicemia. Mechanisms of resistance to cefotaxime are speculated upon because resistance work-up has not yet been completed. SHV, was exclusively isolated in the limited number of strains which have been studied up to now.
1983年，“莱科斯综合”医院发现头孢噻肟对阴沟肠杆菌菌株的耐药率有所上升，同年下半年达到59.3%。所有对头孢噻肟耐药的菌株对头孢孟多、拉氧头孢和头孢曲松均耐药，同时61.8%的菌株对阿米卡星也耐药。尿液是主要的分离源，尤其是来自肾移植科插管患者，其中头孢呋辛大多使用过度。多重耐药菌株具有毒性，因为有5名患者死于败血症。由于耐药性检测尚未完成，目前推测了对头孢噻肟的耐药机制。在目前已研究的有限数量菌株中，仅分离出了SHV。
