Atia Fatma, Bazaraa Hafez, Abdelatty Yara, Lotfy Sarah, Eryan Eman
Department of Pediatrics, Center of Pediatric Nephrology and Transplantation (CPNT), Kasr Al Ainy Faculty of Medicine, Cairo University, Cairo, Egypt.
Cairo University Children Hospital, Kasr Al Ainy, Cairo, Egypt.
BMC Pediatr. 2025 Jan 27;25(1):64. doi: 10.1186/s12887-025-05386-1.
Anemia is prevalent among pediatric patients diagnosed with end-stage kidney disease (ESKD). In addition, erythropoiesis-stimulating agents (ESA) and iron supplementation are considered the cornerstones in the management of anemia. However, a significant proportion of patients remain anemic. Vitamin B6 plays a vital role in the biosynthesis of heme and may be deficient in children with chronic kidney disease (CKD), particularly those on regular hemodialysis (HD). We aimed to evaluate serum vitamin B6 concentration in those children and determine its correlation with anemia indices.
The current cross-sectional study included 39 children on regular HD and 43 healthy controls. Clinical data were collected, including anthropometric measurements, blood pressure, iron, and erythropoietin therapy. Laboratory investigations included hemoglobin (Hb) indices, iron profile, and vitamin B6 level.
The median Hb level in our cohort was 10.5 g/dL, and nine patients had Hb levels at or above the target Hb of 11 g/dl. They had a median Serum Vitamin B6 concentration of 28.2 ng/ml (IQR = 22.8-52.9) compared to a median of 27.5 ng/ml(IQR = 20-34) in controls, with no substantial differences between both groups. There was no statistically significant correlation between vitamin B6 and Hb levels or erythropoietin dose.
It is evident that the majority of our patients did not meet the desired threshold for anemia control. However, it is noteworthy that the average hemoglobin (Hb) level approached the intended target. The incidence of Vitamin B6 deficiency was not found to be statistically significant within our study population. Therefore, we could not establish a correlation between vitamin B6 deficiency and anemia in children on HD.
贫血在诊断为终末期肾病（ESKD）的儿科患者中普遍存在。此外，促红细胞生成素（ESA）和铁补充剂被认为是贫血管理的基石。然而，相当一部分患者仍存在贫血。维生素B6在血红素的生物合成中起着至关重要的作用，慢性肾脏病（CKD）儿童，尤其是接受定期血液透析（HD）的儿童可能缺乏维生素B6。我们旨在评估这些儿童的血清维生素B6浓度，并确定其与贫血指标的相关性。
本横断面研究纳入了39名接受定期血液透析的儿童和43名健康对照。收集了临床数据，包括人体测量、血压、铁和促红细胞生成素治疗情况。实验室检查包括血红蛋白（Hb）指标、铁代谢指标和维生素B6水平。
我们队列中的Hb中位数为10.5 g/dL，9名患者的Hb水平达到或高于目标Hb 11 g/dl。他们的血清维生素B6浓度中位数为28.2 ng/ml（IQR = 22.8 - 52.9），而对照组的中位数为27.5 ng/ml（IQR = 20 - 34），两组之间无显著差异。维生素B6与Hb水平或促红细胞生成素剂量之间无统计学显著相关性。
显然，我们的大多数患者未达到贫血控制的理想阈值。然而，值得注意的是，平均血红蛋白（Hb）水平接近预期目标。在我们的研究人群中，未发现维生素B6缺乏的发生率有统计学意义。因此，我们无法确定HD儿童中维生素B6缺乏与贫血之间的相关性。
