Jia Jia, Lin Runfeng, Liu Minchao, Hou Mengmeng, Yu Hongyue, Lu Qianqian, Ma Yuzhu, Zhao Tiancong, Zhang Fan, Mady Mohamed F, Elzatahry Ahmed A, Wang Jiawen, Ji Yujin, Zhao Dongyuan, Li Xiaomin
Department of Chemistry, Shanghai Stomatological Hospital & School of Stomatology, State Key Laboratory of Molecular Engineering of Polymers, iChem (Collaborative Innovation Center of Chemistry for Energy Materials), Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433, P. R. China.
Department of Chemistry and Earth Sciences, College of Arts and Sciences, Qatar University, P.O. Box 2713, Doha 2713, Qatar.
J Am Chem Soc. 2025 Feb 5;147(5):4198-4209. doi: 10.1021/jacs.4c14011. Epub 2025 Jan 27.
The advent of autonomous nanomotors presents exciting opportunities for nanodrug delivery. However, significant potential remains for enhancing the asymmetry of nanomotors and advancing the development of second near-infrared (NIR-II) light-propelled nanomotors capable of operating within deep tissues. Herein, we developed a dual-ligand assisted anisotropic assembly strategy that enables precise regulation of the interfacial energy between selenium (Se) nanoparticle and periodic mesoporous organosilica (PMO). This strategy facilitates the controllable anisotropic growth of PMO on the Se nanoparticle, leading to the formation of Se&PMO Janus nanohybrids. The exposure ratio of the Se subunit within the Janus nanohybrids can be finely tuned from 0% to 75%. Leveraging the transformability of the Se subunit, a variety of functional MSe&PMO Janus nanocomposites (MSe denotes metal selenide) were further derived. As a proof of concept, CuSe&PMO Janus nanohybrids, with NIR-II photothermal properties, were employed as NIR-II light-driven nanomotors. By precisely controlling the exposure ratio of the CuSe subunit within the Janus nanostructure, these CuSe&PMO nanomotors achieved optimal self-propulsion, thus enhancing cellular uptake and promoting deep tumor penetration. Furthermore, the high loading capacity and hydrophobic framework of the PMO subunit enabled the incorporation of hydrophobic disulfiram, thereby significantly boosting the efficacy of synergistic active-motion photothermal therapy.
自主纳米马达的出现为纳米药物递送带来了令人兴奋的机遇。然而，在增强纳米马达的不对称性以及推进能够在深部组织中运行的第二代近红外（NIR-II）光驱动纳米马达的开发方面，仍有巨大潜力。在此，我们开发了一种双配体辅助各向异性组装策略，该策略能够精确调控硒（Se）纳米颗粒与周期性介孔有机硅（PMO）之间的界面能。这种策略促进了PMO在Se纳米颗粒上可控的各向异性生长，导致形成Se&PMO 双面神纳米杂化物。双面神纳米杂化物中Se亚基的暴露比例可在0%至75%范围内精细调节。利用Se亚基的可转化性，进一步衍生出了多种功能性MSe&PMO双面神纳米复合材料（MSe表示金属硒化物）。作为概念验证，具有NIR-II光热性质的CuSe&PMO双面神纳米杂化物被用作NIR-II光驱动纳米马达。通过精确控制双面神纳米结构中CuSe亚基的暴露比例，这些CuSe&PMO纳米马达实现了最佳的自推进，从而增强了细胞摄取并促进了深部肿瘤渗透。此外，PMO亚基的高负载能力和疏水框架能够包载疏水性双硫仑，从而显著提高协同主动运动光热疗法的疗效。
