Stokes Gabrielle, Herath Madhuni, Samad Navira, Trinh Anne, Milat Frances
Centre for Endocrinology & Metabolism, Hudson Institute of Medical Research, Clayton, Victoria, Australia.
Department of Medicine, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia.
Clin Endocrinol (Oxf). 2025 Apr;102(4):389-402. doi: 10.1111/cen.15203. Epub 2025 Jan 27.
Despite a high burden of osteoporosis and minimal trauma fractures worldwide, there is still a treatment gap in timely diagnosis and optimal treatment. There is also a lack of international consensus and guidelines on the management of bone fragility in premenopausal women. This review article provides an overview of the current understanding of factors impacting women's bone health across the adult lifespan, as well as dilemmas in the diagnosis, assessment and management of osteoporosis in premenopausal and postmenopausal women, premature ovarian insufficiency and bone health following breast cancer.
尽管全球骨质疏松症负担沉重且低创伤骨折发生率高,但在及时诊断和最佳治疗方面仍存在治疗差距。对于绝经前女性骨脆性管理,也缺乏国际共识和指南。这篇综述文章概述了目前对影响成年女性一生骨骼健康的因素的理解,以及绝经前和绝经后女性骨质疏松症、卵巢早衰及乳腺癌后骨骼健康在诊断、评估和管理方面的困境。