Wollesen Bettina, Yellon Tamar, Langeard Antoine, Belkin Vera, Wunderlich Anna, Giannouli Eleftheria, Qian Guoping, Bernades Rafael A, Ossowski Zbigniew, Marusic Uros, Sighdel Rajesh, Netz Yael, Volecker-Rehage Claudia
Human Movement Science, Universitat Hamburg, Hamburg, Hamburg, 20148, Germany.
Institute of Movement Therapy and Movement-oriented Prevention and Rehabilitation, German Sports University Cologne, Cologne, 50933, Germany.
Open Res Eur. 2025 Jan 14;4:202. doi: 10.12688/openreseurope.17823.2. eCollection 2024.
This is a protocol for a living systematic review and meta-analysis.This review will assess the effects of state-of-the-art exercise interventions designed to promote functional mobility. Therefore, after identifying all potential interventions, we will use the F.I.T.T. principles (frequency, intensity, time, type) as well as the physical and health status of the participants as moderators to analyse the mechanisms for the positive benefits of exercise interventions.The main research questions are:Which exercise types are most beneficial for improving functional mobility in various populations of older adults?Which physical exercise characteristics in terms of frequency, intensity, time and duration will achieve the greatest benefit in terms of the defined outcomes, i.e, the functional mobility of older adults?
The systematic literature research according to PRISMA guidelines will search databases like MEDLINE, APA Psych-Info and Web of Science.Inclusion criteria are: healthy older people ≥ 50 years, randomized-controlled trials including exercise intervention and a walking or mobility assessments (eg., TUG, SPPB) as an outcome measure. A preliminary search revealed more than 33,000 hits that will be screened by pairs of independent reviewers. The results will be summarized according to the effects regarding functional mobility and potential dose-response relations via respective meta-analysis.
The systematic review will comprise the knowledge of the existing literature with regards to the effects of the physical activity interventions compared to an active or inactive control group.We will summarize the effects with respect to the F.I.T.T.. They provide a foundation for structuring an optimal exercise training program. If possible, we will also compare interventions from the different categories (eg. cardiovascular, resistance, motor-coordinative, multicomponent or mind-body exercise) as a network analysis and report the influence of moderator variables. Based on the results evidence-based guidelines following GRADE for physical exercise interventions to improve functional mobility in older adults will be provided.
这是一项关于活体系统评价和荟萃分析的方案。本评价将评估旨在促进功能移动性的最新运动干预措施的效果。因此，在确定所有潜在干预措施后，我们将使用F.I.T.T.原则（频率、强度、时间、类型）以及参与者的身体和健康状况作为调节因素，来分析运动干预产生积极效益的机制。主要研究问题如下：
对于不同老年人群体，哪种运动类型对改善功能移动性最有益？
就频率、强度、时间和持续时间而言，哪些体育锻炼特征将在既定结果（即老年人的功能移动性）方面实现最大效益？
根据PRISMA指南进行的系统文献研究将检索MEDLINE、APA Psych-Info和科学网等数据库。纳入标准为：年龄≥50岁的健康老年人、包括运动干预以及将步行或移动性评估（如定时起立行走测试、简短体能状况量表）作为结果指标的随机对照试验。初步检索发现了超过33000条记录，将由独立评审员对其进行成对筛选。结果将通过各自的荟萃分析，根据功能移动性的影响以及潜在的剂量反应关系进行总结。
该系统评价将涵盖与体育活动干预措施与活跃或不活跃对照组相比的效果相关的现有文献知识。我们将总结F.I.T.T.方面的效果。它们为构建最佳运动训练计划提供了基础。如果可能，我们还将作为网络分析比较不同类别（如心血管、阻力、运动协调、多组分或身心运动）的干预措施，并报告调节变量的影响。基于这些结果，将提供遵循GRADE的关于改善老年人功能移动性的体育锻炼干预措施的循证指南。
