Ullah Himayat, Huma Sarwat, Yasin Ghulam, Ashraf Muhammad, Tahir Nafisa, Tahir Uddin Qazi, Shabana Hossam, A R Hussein Mostafa, Shalaby Abdulrahman, Mossaad Alsayyad Mohammad, Said Ashraf, Farahat Ali, Hamed Hani Ismail, Ayoub Hazem Sayed Ahmed, Imam Mohammed S, Elmahdi Essam
Department of Medicine, College of Medicine at Shaqra, Shaqra University, Shaqra 15526, Saudi Arabia.
Health Professions Education, Health Services Academy, Islamabad 44000, Pakistan.
World J Hepatol. 2025 Jan 27;17(1):101212. doi: 10.4254/wjh.v17.i1.101212.
Chronic liver disease is a growing global health problem, leading to hepatic decompensation characterized by an array of clinical and biochemical complications. Several scoring systems have been introduced in assessing the severity of hepatic decompensation with the most frequent ones are Child-Pugh score, model of end-stage liver disease (MELD) score, and MELD-Na score. Anemia is frequently observed in cirrhotic patients and is linked to worsened clinical outcomes. Although studies have explored anemia in liver disease, few have investigated the correlation of hemoglobin level with the severity of hepatic decompensation.
To determine the relationship between hemoglobin levels and the severity of decompensated liver disease and comparing the strength of this correlation using the Child-Pugh, MELD, and MELD-Na scores.
This cross-sectional study was conducted at a tertiary care hospital with 652 decompensated liver disease patients enrolled in the study. Data was collected on demographics, clinical history, and laboratory findings, including hemoglobin levels, bilirubin, albumin, prothrombin time (international normalized ratio), sodium, and creatinine. The Child-Pugh, MELD, and MELD-Na scores were calculated. Statistical analysis was performed using Statistical Package for the Social Sciences version 26, and correlations between hemoglobin levels and severity scores were assessed using Spearman's correlation coefficient.
The study included 405 males (62.1%) and 247 females (37.9%) with an average age of 58.8 years. Significant inverse correlations were found between hemoglobin levels and Child-Pugh, MELD, and MELD-Na scores ( < 0.01), with the MELD scoring system being the strongest correlator among all. One-way analysis of variance revealed significant differences in hemoglobin levels across the severity groups of each scoring system ( = 0.001). Tukey's post hoc analysis confirmed significant internal differences among each severity group.
Understanding the correlation between hemoglobin and liver disease severity can improve patient management by offering insights into prognosis and guiding treatment decisions.
慢性肝病是一个日益严重的全球健康问题，会导致以一系列临床和生化并发症为特征的肝失代偿。在评估肝失代偿的严重程度时引入了几种评分系统，最常用的是Child-Pugh评分、终末期肝病模型（MELD）评分和MELD-Na评分。贫血在肝硬化患者中很常见，并且与临床结局恶化有关。尽管已有研究探讨了肝病中的贫血情况，但很少有研究调查血红蛋白水平与肝失代偿严重程度之间的相关性。
确定血红蛋白水平与失代偿性肝病严重程度之间的关系，并使用Child-Pugh、MELD和MELD-Na评分比较这种相关性的强度。
这项横断面研究在一家三级护理医院进行，共有652例失代偿性肝病患者纳入研究。收集了人口统计学、临床病史和实验室检查结果的数据，包括血红蛋白水平、胆红素、白蛋白、凝血酶原时间（国际标准化比值）、钠和肌酐。计算Child-Pugh、MELD和MELD-Na评分。使用社会科学统计软件包第26版进行统计分析，并使用Spearman相关系数评估血红蛋白水平与严重程度评分之间的相关性。
该研究包括405名男性（62.1%）和247名女性（37.9%），平均年龄为58.8岁。发现血红蛋白水平与Child-Pugh、MELD和MELD-Na评分之间存在显著的负相关（<0.01），其中MELD评分系统在所有系统中相关性最强。单因素方差分析显示，每个评分系统的严重程度组之间血红蛋白水平存在显著差异（=0.001）。Tukey事后分析证实了每个严重程度组之间存在显著的内部差异。
了解血红蛋白与肝病严重程度之间的相关性，可为预后提供见解并指导治疗决策，从而改善患者管理。
