Perazza Federica, Ravaioli Federico
Department of Medical and Surgical Sciences, University of Bologna, Bologna 40138, Italy.
World J Hepatol. 2025 Jan 27;17(1):101195. doi: 10.4254/wjh.v17.i1.101195.
People with advanced chronic liver disease (ACLD) have an enhanced risk of malnutrition, which has multifactorial etiology and is mainly linked to a reduced energy and protein intake; malnutrition is critical for patients with cirrhosis since it is often associated with sarcopenia, a skeletal muscle depletion with a loss of muscle mass and function. Late-evening snacks have been extensively studied, and guidelines are recommended to counteract the effects of prolonged fasting at night in patients with ACLD. However, it has not been fully explored whether late evening snacking is clarified as a milestone to address the nutritional needs of people with ACLD or whether it has a potential role in improving body composition. In this randomised control trial, Yu demonstrated that long-term nocturnal snacks have the potential to significantly improve body composition by body fat mass, visceral fat area and body cell mass in patients with ACLD. While the improvement in skeletal muscle mass was minor, the promising results in other compositions provide hope for future research and patient care.
晚期慢性肝病(ACLD)患者发生营养不良的风险增加,其病因是多因素的,主要与能量和蛋白质摄入减少有关;营养不良对肝硬化患者至关重要,因为它常与肌肉减少症相关,即骨骼肌消耗,伴有肌肉质量和功能丧失。晚间小吃已得到广泛研究,建议制定相关指南以抵消ACLD患者夜间长时间禁食的影响。然而,晚间吃小吃是否可被明确为满足ACLD患者营养需求的一个里程碑,或者它在改善身体成分方面是否具有潜在作用,尚未得到充分探讨。在这项随机对照试验中,Yu证明长期夜间吃小吃有可能显著改善ACLD患者的身体成分,包括体脂肪量、内脏脂肪面积和体细胞量。虽然骨骼肌质量的改善较小,但在其他身体成分方面取得的有前景的结果为未来的研究和患者护理带来了希望。