Szkudelski Tomasz, Szkudelska Katarzyna, Łangowska Aleksandra
Department of Animal Physiology, Biochemistry and Biostructure, Poznań University of Life Sciences, Wołyńska 35, 60-637 Poznań, Poland.
Department of Zoology, Poznań University of Life Sciences, Wojska Polskiego 71C, 60-625 Poznań, Poland.
Int J Mol Sci. 2025 Jul 31;26(15):7391. doi: 10.3390/ijms26157391.
Quercetin is a biologically active flavonoid compound that exerts numerous beneficial effects in humans and animals, including anti-diabetic activity. Its action has been explored in rodent models of type 1 and type 2 diabetes. It was revealed that quercetin mitigated diabetes-related hormonal and metabolic disorders and reduced oxidative and inflammatory stress. Its anti-diabetic effects were associated with advantageous changes in the relevant enzymes and signaling molecules. Quercetin positively affected, among others, superoxide dismutase, catalase, glutathione peroxidase, glucose transporter-2, glucokinase, glucose-6-phosphatase, glycogen phosphorylase, glycogen synthase, glycogen synthase kinase-3β, phosphoenolpyruvate carboxykinase, silent information regulator-1, sterol regulatory element-binding protein-1, insulin receptor substrate 1, phosphoinositide 3-kinase, and protein kinase B. The available data support the conclusion that the action of quercetin was pleiotropic since it alleviates a wide range of diabetes-related disorders. Moreover, no side effects were observed during treatment with quercetin in rodents. Given that human diabetes affects a large part of the population worldwide, the results of animal studies encourage clinical trials to evaluate the potential of quercetin as an adjunct to pharmacological therapies.
槲皮素是一种具有生物活性的黄酮类化合物，对人和动物具有多种有益作用，包括抗糖尿病活性。其作用已在1型和2型糖尿病的啮齿动物模型中进行了探索。结果表明，槲皮素减轻了糖尿病相关的激素和代谢紊乱，并降低了氧化应激和炎症应激。其抗糖尿病作用与相关酶和信号分子的有利变化有关。槲皮素对超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶、葡萄糖转运蛋白-2、葡萄糖激酶、葡萄糖-6-磷酸酶、糖原磷酸化酶、糖原合酶、糖原合酶激酶-3β、磷酸烯醇丙酮酸羧激酶、沉默信息调节因子-1、固醇调节元件结合蛋白-1、胰岛素受体底物1、磷脂酰肌醇3-激酶和蛋白激酶B等产生了积极影响。现有数据支持槲皮素的作用具有多效性这一结论，因为它能减轻多种糖尿病相关疾病。此外，在啮齿动物中用槲皮素治疗期间未观察到副作用。鉴于人类糖尿病影响着全球很大一部分人口，动物研究结果鼓励进行临床试验，以评估槲皮素作为药物治疗辅助手段的潜力。
