Xiong Xuelian, Li Xiaoying
Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Life Metab. 2023 Feb 21;2(1):load007. doi: 10.1093/lifemeta/load007. eCollection 2023 Feb.
Both non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are highly prevalent metabolic liver diseases. Accumulating epidemiological evidence now indicates that NAFLD and T2DM are strongly associated, yet the causative relationship remains to be elucidated. Liver serves as a hub for nutrient and energy metabolism in the body. Here we demonstrated the pathogenesis linking NAFLD to T2DM through a series of studies and the attenuation of T2DM progression after NALFD improvement in cohort study. We proposed the urgent necessity of NAFLD management and NAFLD drug development, which might be novel therapeutic avenues for T2DM.
非酒精性脂肪性肝病（NAFLD）和2型糖尿病（T2DM）都是高度流行的代谢性肝病。越来越多的流行病学证据表明，NAFLD和T2DM密切相关，但其因果关系仍有待阐明。肝脏是人体营养和能量代谢的枢纽。在此，我们通过一系列研究证明了NAFLD与T2DM之间的发病机制联系，并在队列研究中发现NAFLD改善后T2DM进展得到缓解。我们提出了对NAFLD进行管理和开发NAFLD药物的迫切必要性，这可能是治疗T2DM的新途径。
