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Is pig organ xenotransplantation era approaching?

作者信息

Hu Zheng, Fang Minghui, Xu Fei, Yamada Kazuhiko, Yang Yong-Guang

机构信息

Key Laboratory of Organ Regeneration & Transplantation of Ministry of Education, and National-Local Joint Engineering Laboratory of Animal Models for Human Diseases, The First Hospital of Jilin University, Changchun 130061, China.

Columbia Center for Translational Immunology, Columbia University Medical Center, New York 10032, United States.

出版信息

Life Med. 2022 Aug 19;1(3):241-243. doi: 10.1093/lifemedi/lnac032. eCollection 2022 Dec.

DOI:10.1093/lifemedi/lnac032
PMID:39872739
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11749106/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05a4/11749106/b568e6285920/lnac032_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05a4/11749106/b568e6285920/lnac032_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05a4/11749106/b568e6285920/lnac032_fig1.jpg

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1
Is pig organ xenotransplantation era approaching?猪器官异种移植时代即将来临？
Life Med. 2022 Aug 19;1(3):241-243. doi: 10.1093/lifemedi/lnac032. eCollection 2022 Dec.
2
Report of the Xenotransplantation Advisory Committee of the International Society for Heart and Lung Transplantation: the present status of xenotransplantation and its potential role in the treatment of end-stage cardiac and pulmonary diseases.国际心肺移植学会异种移植咨询委员会报告：异种移植的现状及其在终末期心脏和肺部疾病治疗中的潜在作用。
J Heart Lung Transplant. 2000 Dec;19(12):1125-65. doi: 10.1016/s1053-2498(00)00224-2.
3
Contributions of Europeans to Xenotransplantation Research: 2. Pig Islet and Cell Xenotransplantation.欧洲人对异种移植研究的贡献：2. 猪胰岛和细胞异种移植。
Transpl Int. 2025 Apr 17;38:14143. doi: 10.3389/ti.2025.14143. eCollection 2025.
4
Xenotransplantation in China: Present status.中国的异种移植：现状。
Xenotransplantation. 2019 Jan;26(1):e12490. doi: 10.1111/xen.12490. Epub 2019 Feb 11.
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Frankenswine, or bringing home the bacon: How close are we to clinical trials in xenotransplantation?弗兰肯猪，或带来培根：异种移植临床试验我们还差多远？
Organogenesis. 2008 Jan;4(1):1-10. doi: 10.4161/org.5383.
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Is Allosensitization Detrimental to Pig Organ Xenotransplantation, and Is Xenosensitization Detrimental to Subsequent Organ Allotransplantation? A Debate Organized by the International Xenotransplantation Association (IXA).同种异体致敏是否对猪器官异种移植有害，以及异种致敏是否对随后的器官同种移植有害？由国际异种移植协会 (IXA) 组织的辩论。
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Comp Med. 2019 Apr 1;69(2):86-94. doi: 10.30802/AALAS-CM-18-000093. Epub 2019 Mar 25.
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How Much Will a Pig Organ Transplant Cost? A Preliminary Estimate of the Cost of Xenotransplantation Versus Allotransplantation in the USA.猪器官移植的成本会是多少？美国异种移植与同种异体移植成本的初步估计。
Xenotransplantation. 2025 Jan-Feb;32(1):e70018. doi: 10.1111/xen.70018.
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Contributions of Europeans to Xenotransplantation Research: 1. Pig Organ Xenotransplantation.欧洲人对异种移植研究的贡献：1. 猪器官异种移植
Transpl Int. 2025 Feb 27;38:14041. doi: 10.3389/ti.2025.14041. eCollection 2025.
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Xenotransplantation of solid organs in the pig-to-primate model.猪到灵长类动物模型中的实体器官异种移植。
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引用本文的文献

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Life Med. 2025 Mar 31;4(3):lnaf016. doi: 10.1093/lifemedi/lnaf016. eCollection 2025 Jun.

本文引用的文献

1
Genetically Modified Porcine-to-Human Cardiac Xenotransplantation.基因编辑猪-人心脏异种移植。
N Engl J Med. 2022 Jul 7;387(1):35-44. doi: 10.1056/NEJMoa2201422. Epub 2022 Jun 22.
2
Results of Two Cases of Pig-to-Human Kidney Xenotransplantation.猪到人肾异种移植的两例结果。
N Engl J Med. 2022 May 19;386(20):1889-1898. doi: 10.1056/NEJMoa2120238.
3
Progressive genetic modifications of porcine cardiac xenografts extend survival to 9 months.猪心异种移植物的渐进式遗传修饰将存活时间延长至 9 个月。
Xenotransplantation. 2022 May;29(3):e12744. doi: 10.1111/xen.12744. Epub 2022 Mar 31.
4
Measuring success in pig to non-human-primate renal xenotransplantation: Systematic review and comparative outcomes analysis of 1051 life-sustaining NHP renal allo- and xeno-transplants.衡量猪到非人类灵长类动物肾异种移植的成功：1051 例维持生命的 NHPr 同种和异种移植的系统评价和比较结果分析。
Am J Transplant. 2022 Jun;22(6):1527-1536. doi: 10.1111/ajt.16994. Epub 2022 Feb 28.
5
First clinical-grade porcine kidney xenotransplant using a human decedent model.首例临床级猪肾异种移植采用人尸体模型。
Am J Transplant. 2022 Apr;22(4):1037-1053. doi: 10.1111/ajt.16930. Epub 2022 Jan 20.
6
Anti-C5 Antibody Tesidolumab Reduces Early Antibody-mediated Rejection and Prolongs Survival in Renal Xenotransplantation.抗 C5 抗体 Tesidolumab 减少肾异种移植中的早期抗体介导排斥反应并延长生存时间。
Ann Surg. 2021 Sep 1;274(3):473-480. doi: 10.1097/SLA.0000000000004996.
7
Xenotransplantation: past, present, and future.异种移植：过去、现在与未来。
Curr Opin Organ Transplant. 2017 Dec;22(6):513-521. doi: 10.1097/MOT.0000000000000463.
8
Xenotransplantation: immunological hurdles and progress toward tolerance.异种移植：免疫障碍与免疫耐受的进展
Immunol Rev. 2014 Mar;258(1):241-58. doi: 10.1111/imr.12152.
9
Xenotransplantation: current status and a perspective on the future.异种移植：现状与未来展望
Nat Rev Immunol. 2007 Jul;7(7):519-31. doi: 10.1038/nri2099.
10
Thymic transplantation in miniature swine. I. Development and function of the "thymokidney".小型猪的胸腺移植。I. “胸腺肾”的发育与功能。
Transplantation. 1999 Dec 15;68(11):1684-92. doi: 10.1097/00007890-199912150-00011.