Zhang Weiwei, Che Yang, Tang Xiaoqiang, Chen Siqi, Song Moshi, Wang Li, Sun Ai-Jun, Chen Hou-Zao, Xu Ming, Wang Miao, Pu Jun, Li Zijian, Xiao Junjie, Cao Chun-Mei, Zhang Yan, Lu Yao, Zhao Yingxin, Wang Yan-Jiang, Zhang Cuntai, Shen Tao, Zhang Weiqi, Tao Ling, Qu Jing, Tang Yi-Da, Liu Guang-Hui, Pei Gang, Li Jian, Cao Feng
Department of Cardiology, The Second Medical Centre, Chinese PLA General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing 100853, China.
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Life Med. 2023 Sep 27;2(5):lnad035. doi: 10.1093/lifemedi/lnad035. eCollection 2023 Oct.
Cardiac aging constitutes a significant risk factor for cardiovascular diseases prevalent among the elderly population. Urgent attention is required to prioritize preventive and management strategies for age-related cardiovascular conditions to safeguard the well-being of elderly individuals. In response to this critical challenge, the Aging Biomarker Consortium (ABC) of China has formulated an expert consensus on cardiac aging biomarkers. This consensus draws upon the latest scientific literature and clinical expertise to provide a comprehensive assessment of biomarkers associated with cardiac aging. Furthermore, it presents a standardized methodology for characterizing biomarkers across three dimensions: functional, structural, and humoral. The functional dimension encompasses a broad spectrum of markers that reflect diastolic and systolic functions, sinus node pacing, neuroendocrine secretion, coronary microcirculation, and cardiac metabolism. The structural domain emphasizes imaging markers relevant to concentric cardiac remodeling, coronary artery calcification, and epicardial fat deposition. The humoral aspect underscores various systemic () and heart-specific () markers, including endocrine hormones, cytokines, and other plasma metabolites. The ABC's primary objective is to establish a robust foundation for assessing cardiac aging, thereby furnishing a dependable reference for clinical applications and future research endeavors. This aims to contribute significantly to the enhancement of cardiovascular health and overall well-being among elderly individuals.
心脏衰老构成了老年人群中普遍存在的心血管疾病的一个重要风险因素。迫切需要关注与年龄相关的心血管疾病的预防和管理策略的优先级，以保障老年人的健康。为应对这一严峻挑战，中国衰老生物标志物联盟（ABC）制定了关于心脏衰老生物标志物的专家共识。该共识借鉴了最新的科学文献和临床专业知识，对与心脏衰老相关的生物标志物进行了全面评估。此外，它还提出了一种在功能、结构和体液三个维度上表征生物标志物的标准化方法。功能维度包括反映舒张和收缩功能、窦房结起搏、神经内分泌分泌、冠状动脉微循环和心脏代谢的广泛标志物。结构领域强调与向心性心脏重塑、冠状动脉钙化和心外膜脂肪沉积相关的成像标志物。体液方面强调各种全身（）和心脏特异性（）标志物，包括内分泌激素、细胞因子和其他血浆代谢物。ABC的主要目标是为评估心脏衰老建立一个坚实的基础，从而为临床应用和未来的研究工作提供可靠的参考。这旨在为提高老年人的心血管健康和整体健康做出重大贡献。
