犬类柯克斯体病——印度一种迄今被掩盖的人畜共患病：血清分子学调查与风险因素分析的见解
Coxiellosis in Dogs-A Hitherto Masked Zoonosis in India: An Insight From Seromolecular Investigation and Risk Factor Analysis.
作者信息
Vinod Valil Kunjukunju, Malik Satyaveer Singh, Sivaprasad M S, Malik Chinmay, Parmar Neha, Mathesh Karikalan, Kumar Brijesh, De Ujjwal Kumar, Sanjumon E S, Vergis Jess, Barbuddhe Sukhadeo Baliram, Rawool Deepak Bhiwa
机构信息
Division of Veterinary Public Health, ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, India.
Pre-Med Scholar, College of Health Solutions, Arizona State University, 1151 S Forest Ave, Tempe, Arizona, USA.
出版信息
Can J Infect Dis Med Microbiol. 2025 Jan 20;2025:8642619. doi: 10.1155/cjid/8642619. eCollection 2025.
is an airborne bacterial zoonotic pathogen that causes Q fever/coxiellosis in humans and animals. Although dogs are suspected of transmitting Q fever to humans in past outbreaks, the prevalence of in the Indian dog population and risk factors for infection remain unknown. In this study, 452 dogs from pet clinics in three Indian states were screened for coxiellosis using molecular (Trans-PCR, Com 1-PCR) and serological (IFAT) tests. DNA was detected in 0.44% of blood samples using Trans-PCR, and pathogen-specific antibodies were found in 4.20% of sera using IFAT. Contact with stray dogs and ownership by farmers were identified as risk factors for canine coxiellosis. This study appears to be the first systematic assessment of coxiellosis and associated risk factors among dogs in India. A large-scale assessment of canine coxiellosis and its risk factors is warranted among pets and high-risk occupational groups in India.
是一种空气传播的细菌性人畜共患病原体，可导致人类和动物患Q热/柯克斯体病。尽管在过去的疫情爆发中怀疑狗会将Q热传播给人类，但印度犬类群体中的患病率以及感染的风险因素仍然未知。在这项研究中，对来自印度三个邦宠物诊所的452只狗使用分子检测（转录-PCR、Com 1-PCR）和血清学检测（间接免疫荧光试验）进行了柯克斯体病筛查。使用转录-PCR在0.44%的血液样本中检测到了DNA，使用间接免疫荧光试验在4.20%的血清中发现了病原体特异性抗体。与流浪狗接触以及农民养狗被确定为犬类柯克斯体病的风险因素。这项研究似乎是对印度犬类柯克斯体病及其相关风险因素的首次系统评估。有必要在印度的宠物和高风险职业群体中对犬类柯克斯体病及其风险因素进行大规模评估。
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