Wu Shaofang, Ye Xin, Liu Xinyang, Dai Luyi, Chen Huan
Department of dermatology, Lishui Central Hospital, Lishui, 323000, China.
Arch Dermatol Res. 2025 Jan 28;317(1):309. doi: 10.1007/s00403-024-03749-9.
The purpose of this study was to evaluate dermatologists' knowledge, attitudes, and practices (KAP) concerning omalizumab therapy for chronic urticaria. We conducted a cross-sectional study in several hospitals in China, mainly in hospitals in Zhejiang Province, during August 1, 2024 - August 15, 2024 using a self-administered KAP questionnaire. Wilcoxon-Mann-Whitney tests and Kruskal-Wallis analysis of variance were performed to compare differences across groups Factors influencing practice were determined through multivariable logistic regression. The study analyzed 354 valid questionnaires. Among the respondents, 248 (70.06%) were aged between 31 and 35 years, and 269 (75.99%) had 5-10 years of experience. The mean scores for knowledge, attitudes, and practices were 5.71 ± 1.39 (possible range: 0-9), 21.39 ± 2.25 (possible range: 5-25), and 19.84 ± 2.53 (possible range: 5-25), respectively. Multivariate logistic regression indicated that a higher attitude score (OR = 1.929, 95% CI: [1.511-2.462], P < 0.001), being male (OR = 3.262, 95% CI: [1.507-7.059], P = 0.003), and awareness of omalizumab (OR = 4.966, 95% CI: [1.466-16.830], P = 0.010) were significantly associated with proactive practice. Dermatologists demonstrated insufficient knowledge, positive attitudes, and proactive practices towards omalizumab therapy for chronic urticaria. Given the identified knowledge gap, there is a pressing need for targeted educational interventions to enhance dermatologists' understanding of omalizumab therapy for chronic urticaria, aiming to improve patient care and outcomes in clinical practice.
本研究的目的是评估皮肤科医生对奥马珠单抗治疗慢性荨麻疹的知识、态度和实践（KAP）。2024年8月1日至2024年8月15日期间，我们在中国的几家医院，主要是浙江省的医院，采用自行填写的KAP问卷进行了一项横断面研究。进行Wilcoxon-Mann-Whitney检验和Kruskal-Wallis方差分析以比较各组之间的差异。通过多变量逻辑回归确定影响实践的因素。该研究分析了354份有效问卷。在受访者中，248人（70.06%）年龄在31至35岁之间，269人（75.99%）有5至10年的工作经验。知识、态度和实践的平均得分分别为5.71±1.39（可能范围：0至9）、21.39±2.25（可能范围：5至25）和19.84±2.53（可能范围：5至25）。多变量逻辑回归表明，较高的态度得分（OR = 1.929，95% CI：[1.511 - 2.462]，P < 0.001）、男性（OR = 3.262，95% CI：[1.507 - 7.059]，P = 0.003）以及对奥马珠单抗的知晓（OR = 4.966，95% CI：[1.466 - 16.830]，P = 0.010）与积极实践显著相关。皮肤科医生对奥马珠单抗治疗慢性荨麻疹的知识不足，但态度积极且实践主动。鉴于已发现的知识差距，迫切需要有针对性的教育干预措施，以增强皮肤科医生对奥马珠单抗治疗慢性荨麻疹的理解，旨在改善临床实践中的患者护理和治疗效果。
