Jiang Yanqiong, Liu Pengfei, Zeng Meihong, Zhuang Guiying, Qiu Cuiqing, Wang Liyun, Liu Weiling, Liu Weiqi
Division of Neonatology, The Maternal and Children Health Care Hospital (Huzhong Hospital) of Huadu, Guangzhou, Guangdong, People's Republic of China.
Department of Laboratory Medicine, The Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, People's Republic of China.
Sci Rep. 2025 Jan 28;15(1):3497. doi: 10.1038/s41598-025-87955-z.
Studies investigating the relationship between exposure to air pollutants during pregnancy and foetal growth restriction (FGR) in women who conceive by in vitro fertilisation (IVF) are lacking. The objective was to investigate the effect of air pollutant exposure in pregnancy on FGR in pregnant women who conceive by IVF. We included pregnant women who conceived by IVF and delivered healthy singleton babies in Guangzhou from October 2018 to September 2023. We also collected data on air pollutant concentrations in Guangzhou during the same period. We analysed the impact of air pollution exposure during pregnancy on FGR. After adjusting for confounders, our analysis showed that in the first trimester, high concentrations of PM and NO in the fourth quartile significantly increased the risk of FGR. Specifically, the odds ratios were 6.430 (95% confidence interval [CI]: 1.035-39.96) for PM and 10.73 (95% CI: 1.230-93.48) for NO. In the second trimester, exposure to PM, PM, and NO was associated with an increased risk of FGR. In addition, subgroup analyses showed that exposure to NO during pregnancy increased the risk of FGR in women aged 35 years and older. The results of this cross-sectional study suggest that exposure to PM, PM, and NO in pregnant women who conceive by IVF is associated with the occurrence of FGR.
关于体外受精（IVF）受孕女性孕期暴露于空气污染物与胎儿生长受限（FGR）之间关系的研究尚属空白。本研究旨在探讨IVF受孕孕妇孕期暴露于空气污染物对FGR的影响。我们纳入了2018年10月至2023年9月在广州通过IVF受孕并分娩健康单胎婴儿的孕妇。我们还收集了同期广州空气污染物浓度的数据。我们分析了孕期空气污染暴露对FGR的影响。在对混杂因素进行校正后，我们的分析表明，在孕早期，第四四分位数的高浓度PM和NO显著增加了FGR的风险。具体而言，PM的比值比为6.430（95%置信区间[CI]：1.035 - 39.96），NO的比值比为10.73（95%CI：1.230 - 93.48）。在孕中期，暴露于PM、PM和NO与FGR风险增加相关。此外，亚组分析表明，孕期暴露于NO会增加35岁及以上女性发生FGR的风险。这项横断面研究的结果表明，IVF受孕孕妇暴露于PM、PM和NO与FGR的发生有关。
