Been M, Macfarlane P W, Hillis W S
Drugs. 1985;29 Suppl 2:76-80. doi: 10.2165/00003495-198500292-00014.
Oral felodipine (10mg) was given to 11 patients undergoing routine invasive electrophysiological studies. Systolic blood pressure fell by 31 mm Hg from 130 +/- 17.5 to 99 +/- 10 mm Hg (mean +/- SD, p less than 0.001) while diastolic pressure fell from 78 +/- 9 to 60 +/- 8mm Hg (p less than 0.001), thus confirming its vasodilator properties. Heart increased from 64 +/- 10 to 78 +/- 16 beats/min (p less than 0.001). The A-H interval was significantly prolonged from 97 +/- 14 to 110 +/- 24 msec (p less than 0.01) while there was no change in the H-V interval. Sinus node recovery time showed no change when corrected for heart rate. The effective refractory period of the atrioventricular node was shortened from 317 +/- 38 to 287 +/- 27 msec (p less than 0.01) as was the effective refractory period of the ventricular Purkinje fibres from 251 +/- 18 to 237 +/- 20 msec (p less than 0.005). These haemodynamic and electrophysiological changes suggest that this compound is an effective vasodilator and may have potential antiarrhythmic properties.
对11例接受常规有创电生理检查的患者给予口服非洛地平（10毫克）。收缩压从130±17.5毫米汞柱降至99±10毫米汞柱，下降了31毫米汞柱（均值±标准差，p<0.001），而舒张压从78±9毫米汞柱降至60±8毫米汞柱（p<0.001），从而证实了其血管舒张特性。心率从64±10次/分钟增至78±16次/分钟（p<0.001）。A-H间期从97±14毫秒显著延长至110±24毫秒（p<0.01），而H-V间期无变化。经心率校正后，窦房结恢复时间无变化。房室结的有效不应期从317±38毫秒缩短至287±27毫秒（p<0.01），心室浦肯野纤维的有效不应期也从251±18毫秒缩短至237±20毫秒（p<0.005）。这些血流动力学和电生理变化表明，该化合物是一种有效的血管舒张剂，可能具有潜在的抗心律失常特性。
